Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma: A retrospective cohort study

Young J Juhn, Diana Frey, Xujian Li, Robert Jacobson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Patients with asthma have an increased risk of Streptococcus pyogenes infection compared with those without asthma. It is unknown whether this is true for children with other atopic conditions such as atopic dermatitis or allergic rhinitis. Aims: To determine the risk of developing S. pyogenes infections of the upper respiratory tract in children and adolescents with atopic dermatitis and/or allergic rhinitis. Methods: We conducted a retrospective cohort study that followed a convenience sample of 340 healthy children. Atopic dermatitis or eczema and allergic rhinitis or hay fever were determined based on a physician diagnosis documented in medical records. All laboratory test results of cultures, rapid antigen detection, and polymerase chain reaction tests for S. pyogenes infections during the first 18 years of life were collected to compare the incidence of S. pyogenes infections between children with and without a physician diagnosis of atopic conditions. A Poisson regression was fit to determine the association between asthma and S. pyogenes infections, controlling for other covariates including asthma. Results: Of the 340 subjects, 327 were eligible for the study. Of these 327 subjects, 143 (44%) had atopic conditions other than asthma. The incidence of S. pyogenes infections in children with atopic conditions other than asthma and those without atopic conditions was 0.24 per person-year and 0.18 per person-year, respectively. The adjusted risk ratios for allergic rhinitis and atopic dermatitis were 1.36 (95% CI 1.07 to 1.66, p=0.011) and 1.30 (95% CI 0.98 to 1.71, p=0.06), respectively, controlling for asthma and other covariates. Conclusions: In addition to asthma, allergic rhinitis but not atopic dermatitis is associated with an increased risk of S. pyogenes upper respiratory tract infections.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalPrimary Care Respiratory Journal
Volume21
Issue number2
DOIs
StatePublished - Jun 2012

Fingerprint

Streptococcus pyogenes
Respiratory Tract Infections
Cohort Studies
Atopic Dermatitis
Asthma
Retrospective Studies
Infection
Physicians
Seasonal Allergic Rhinitis
Incidence
Medical Records
Odds Ratio
Allergic Rhinitis
Antigens
Polymerase Chain Reaction

Keywords

  • Allergic rhinitis
  • Atopic dermatitis
  • Children
  • Infection
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

Cite this

Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma : A retrospective cohort study. / Juhn, Young J; Frey, Diana; Li, Xujian; Jacobson, Robert.

In: Primary Care Respiratory Journal, Vol. 21, No. 2, 06.2012, p. 153-158.

Research output: Contribution to journalArticle

@article{bf8b6e6ffeeb42deb088f1ac691851a5,
title = "Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma: A retrospective cohort study",
abstract = "Background: Patients with asthma have an increased risk of Streptococcus pyogenes infection compared with those without asthma. It is unknown whether this is true for children with other atopic conditions such as atopic dermatitis or allergic rhinitis. Aims: To determine the risk of developing S. pyogenes infections of the upper respiratory tract in children and adolescents with atopic dermatitis and/or allergic rhinitis. Methods: We conducted a retrospective cohort study that followed a convenience sample of 340 healthy children. Atopic dermatitis or eczema and allergic rhinitis or hay fever were determined based on a physician diagnosis documented in medical records. All laboratory test results of cultures, rapid antigen detection, and polymerase chain reaction tests for S. pyogenes infections during the first 18 years of life were collected to compare the incidence of S. pyogenes infections between children with and without a physician diagnosis of atopic conditions. A Poisson regression was fit to determine the association between asthma and S. pyogenes infections, controlling for other covariates including asthma. Results: Of the 340 subjects, 327 were eligible for the study. Of these 327 subjects, 143 (44{\%}) had atopic conditions other than asthma. The incidence of S. pyogenes infections in children with atopic conditions other than asthma and those without atopic conditions was 0.24 per person-year and 0.18 per person-year, respectively. The adjusted risk ratios for allergic rhinitis and atopic dermatitis were 1.36 (95{\%} CI 1.07 to 1.66, p=0.011) and 1.30 (95{\%} CI 0.98 to 1.71, p=0.06), respectively, controlling for asthma and other covariates. Conclusions: In addition to asthma, allergic rhinitis but not atopic dermatitis is associated with an increased risk of S. pyogenes upper respiratory tract infections.",
keywords = "Allergic rhinitis, Atopic dermatitis, Children, Infection, Streptococcus pyogenes",
author = "Juhn, {Young J} and Diana Frey and Xujian Li and Robert Jacobson",
year = "2012",
month = "6",
doi = "10.4104/pcrj.2011.00110",
language = "English (US)",
volume = "21",
pages = "153--158",
journal = "Asthma in General Practice",
issn = "1471-4418",
publisher = "Primary Care Respiratory Society UK",
number = "2",

}

TY - JOUR

T1 - Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma

T2 - A retrospective cohort study

AU - Juhn, Young J

AU - Frey, Diana

AU - Li, Xujian

AU - Jacobson, Robert

PY - 2012/6

Y1 - 2012/6

N2 - Background: Patients with asthma have an increased risk of Streptococcus pyogenes infection compared with those without asthma. It is unknown whether this is true for children with other atopic conditions such as atopic dermatitis or allergic rhinitis. Aims: To determine the risk of developing S. pyogenes infections of the upper respiratory tract in children and adolescents with atopic dermatitis and/or allergic rhinitis. Methods: We conducted a retrospective cohort study that followed a convenience sample of 340 healthy children. Atopic dermatitis or eczema and allergic rhinitis or hay fever were determined based on a physician diagnosis documented in medical records. All laboratory test results of cultures, rapid antigen detection, and polymerase chain reaction tests for S. pyogenes infections during the first 18 years of life were collected to compare the incidence of S. pyogenes infections between children with and without a physician diagnosis of atopic conditions. A Poisson regression was fit to determine the association between asthma and S. pyogenes infections, controlling for other covariates including asthma. Results: Of the 340 subjects, 327 were eligible for the study. Of these 327 subjects, 143 (44%) had atopic conditions other than asthma. The incidence of S. pyogenes infections in children with atopic conditions other than asthma and those without atopic conditions was 0.24 per person-year and 0.18 per person-year, respectively. The adjusted risk ratios for allergic rhinitis and atopic dermatitis were 1.36 (95% CI 1.07 to 1.66, p=0.011) and 1.30 (95% CI 0.98 to 1.71, p=0.06), respectively, controlling for asthma and other covariates. Conclusions: In addition to asthma, allergic rhinitis but not atopic dermatitis is associated with an increased risk of S. pyogenes upper respiratory tract infections.

AB - Background: Patients with asthma have an increased risk of Streptococcus pyogenes infection compared with those without asthma. It is unknown whether this is true for children with other atopic conditions such as atopic dermatitis or allergic rhinitis. Aims: To determine the risk of developing S. pyogenes infections of the upper respiratory tract in children and adolescents with atopic dermatitis and/or allergic rhinitis. Methods: We conducted a retrospective cohort study that followed a convenience sample of 340 healthy children. Atopic dermatitis or eczema and allergic rhinitis or hay fever were determined based on a physician diagnosis documented in medical records. All laboratory test results of cultures, rapid antigen detection, and polymerase chain reaction tests for S. pyogenes infections during the first 18 years of life were collected to compare the incidence of S. pyogenes infections between children with and without a physician diagnosis of atopic conditions. A Poisson regression was fit to determine the association between asthma and S. pyogenes infections, controlling for other covariates including asthma. Results: Of the 340 subjects, 327 were eligible for the study. Of these 327 subjects, 143 (44%) had atopic conditions other than asthma. The incidence of S. pyogenes infections in children with atopic conditions other than asthma and those without atopic conditions was 0.24 per person-year and 0.18 per person-year, respectively. The adjusted risk ratios for allergic rhinitis and atopic dermatitis were 1.36 (95% CI 1.07 to 1.66, p=0.011) and 1.30 (95% CI 0.98 to 1.71, p=0.06), respectively, controlling for asthma and other covariates. Conclusions: In addition to asthma, allergic rhinitis but not atopic dermatitis is associated with an increased risk of S. pyogenes upper respiratory tract infections.

KW - Allergic rhinitis

KW - Atopic dermatitis

KW - Children

KW - Infection

KW - Streptococcus pyogenes

UR - http://www.scopus.com/inward/record.url?scp=84862777606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862777606&partnerID=8YFLogxK

U2 - 10.4104/pcrj.2011.00110

DO - 10.4104/pcrj.2011.00110

M3 - Article

C2 - 22270478

AN - SCOPUS:84862777606

VL - 21

SP - 153

EP - 158

JO - Asthma in General Practice

JF - Asthma in General Practice

SN - 1471-4418

IS - 2

ER -