Strategies for treatment-resistant depression

Christos Ballas, Jeffrey P Staab, Dwight L. Evans

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Approximately 30% of patients with major depression respond poorly to treatment with any given antidepressant regimen, and as many as 60% to 75% experience residual or recurrent symptoms. Strategies for improving response include extending the duration of each treatment beyond the usual 2-4 weeks, increasing the antidepressant dose, switching to another antidepressant, using two or more antidepressants together, and using adjunctive medications or other treatment modalities. Some of these strategies have strong support from clinical investigations while others are based more on clinical experience. This article reviews the risk factors for treatment resistance and provides strategies for improving treatment outcomes.

Original languageEnglish (US)
Pages (from-to)39-62
Number of pages24
JournalPsychopharmacology Bulletin
Volume36
Issue number4
StatePublished - Sep 1 2002
Externally publishedYes

Fingerprint

Treatment-Resistant Depressive Disorder
Antidepressive Agents
Therapeutics
Depression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Strategies for treatment-resistant depression. / Ballas, Christos; Staab, Jeffrey P; Evans, Dwight L.

In: Psychopharmacology Bulletin, Vol. 36, No. 4, 01.09.2002, p. 39-62.

Research output: Contribution to journalArticle

Ballas, C, Staab, JP & Evans, DL 2002, 'Strategies for treatment-resistant depression', Psychopharmacology Bulletin, vol. 36, no. 4, pp. 39-62.
Ballas, Christos ; Staab, Jeffrey P ; Evans, Dwight L. / Strategies for treatment-resistant depression. In: Psychopharmacology Bulletin. 2002 ; Vol. 36, No. 4. pp. 39-62.
@article{dc0ca612ccee49c7aa4eb4773545e675,
title = "Strategies for treatment-resistant depression",
abstract = "Approximately 30{\%} of patients with major depression respond poorly to treatment with any given antidepressant regimen, and as many as 60{\%} to 75{\%} experience residual or recurrent symptoms. Strategies for improving response include extending the duration of each treatment beyond the usual 2-4 weeks, increasing the antidepressant dose, switching to another antidepressant, using two or more antidepressants together, and using adjunctive medications or other treatment modalities. Some of these strategies have strong support from clinical investigations while others are based more on clinical experience. This article reviews the risk factors for treatment resistance and provides strategies for improving treatment outcomes.",
author = "Christos Ballas and Staab, {Jeffrey P} and Evans, {Dwight L.}",
year = "2002",
month = "9",
day = "1",
language = "English (US)",
volume = "36",
pages = "39--62",
journal = "Psychopharmacology Bulletin",
issn = "0048-5764",
publisher = "MedWorks Media LLC",
number = "4",

}

TY - JOUR

T1 - Strategies for treatment-resistant depression

AU - Ballas, Christos

AU - Staab, Jeffrey P

AU - Evans, Dwight L.

PY - 2002/9/1

Y1 - 2002/9/1

N2 - Approximately 30% of patients with major depression respond poorly to treatment with any given antidepressant regimen, and as many as 60% to 75% experience residual or recurrent symptoms. Strategies for improving response include extending the duration of each treatment beyond the usual 2-4 weeks, increasing the antidepressant dose, switching to another antidepressant, using two or more antidepressants together, and using adjunctive medications or other treatment modalities. Some of these strategies have strong support from clinical investigations while others are based more on clinical experience. This article reviews the risk factors for treatment resistance and provides strategies for improving treatment outcomes.

AB - Approximately 30% of patients with major depression respond poorly to treatment with any given antidepressant regimen, and as many as 60% to 75% experience residual or recurrent symptoms. Strategies for improving response include extending the duration of each treatment beyond the usual 2-4 weeks, increasing the antidepressant dose, switching to another antidepressant, using two or more antidepressants together, and using adjunctive medications or other treatment modalities. Some of these strategies have strong support from clinical investigations while others are based more on clinical experience. This article reviews the risk factors for treatment resistance and provides strategies for improving treatment outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84965187877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965187877&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 39

EP - 62

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

SN - 0048-5764

IS - 4

ER -