Strategies for improving outcomes in NSCLC: A look to the future

Rolf Stahel, Solange Peters, Paul Baas, Elisabeth Brambilla, Federico Cappuzzo, Dirk De Ruysscher, Wilfried Ernst Erich Eberhardt, Enriqueta Felip, Dean Fennell, Antonio Marchetti, Luis Paz-Ares, Alex A. Adjei

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Advances in the management of non-small cell lung cancer (NSCLC) over the past 30 years have led to small increases in 5-year survival rates across Europe, though further improvements may require new treatment strategies. In order to improve efficiency and reduce the cost of development, future trials for new targeted agents in NSCLC should aim to recruit patients on the basis of tumour biology rather than clinical characteristics. However, identification of predictive biomarkers is required to maximise the benefits of new approaches and expedite the drug development process. Nevertheless, the NSCLC landscape is changing rapidly, and recent improvements in our understanding of the molecular biology of the disease will help in the identification of novel targeted agents as well as assisting in the development of personalised strategies for the numerous small subsets of defined NSCLC. Progress in imaging and treatment delivery is also likely to improve outcomes for patients with the disease. This article outlines recent progress in the treatment of NSCLC, identifies current challenges and describes proposals for improving the future management of the disease. It is hoped that implementation of some of these strategies will go some way to improving the outlook for patients with NSCLC.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalLung Cancer
Volume82
Issue number3
DOIs
StatePublished - Dec 2013

Keywords

  • Biomarkers
  • Clinical trials
  • Lung cancer
  • Management
  • Molecular profiling
  • Outcomes
  • Pathogenesis
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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