Strabismus incidence in a Danish population-based cohort of children

Tobias Torp-Pedersen, Heather A. Boyd, Line Skotte, Birgitte Haargaard, Jan Wohlfahrt, Jonathan M Holmes, Mads Melbye

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

IMPORTANCE: To our knowledge, there have been few population-based studies of strabismus incidence conducted. Our population-based study provides valuable data for health services planning and identifying research needs. OBJECTIVE: To determine the incidence and age distribution of strabismus, overall and by subtype, among children 7 years or younger. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study was conducted with data from 96 842 children enrolled in the Danish National Birth Cohort. MAIN OUTCOMES AND MEASURES: Age-specific incidence and cumulative incidence and median age at the detection of strabismus, overall and by subtype. RESULTS: The study cohort included 96 842 children born between 1996 and 2008 who are predominantly Caucasian and is composed of approximately 30% of births in Denmark, with a boy-girl ratio of 51:49. Overall, 1309 cases of strabismus were identified in the cohort. We found an overall cumulative strabismus incidence of 2.56% (95% CI, 2.42-2.69) at 7 years. The overall incidence was similar among boys and girls. Two hundred sixteen participants (16.5%) (95% CI, 14.5-18.6) had congenital esotropia, 177 (13.5%) (95% CI, 11.7-15.5) had fully accommodative esotropia, 252 (19.3%) (95% CI, 17.1-21.5) had partially accommodative esotropia, and 181 (13.8%) (95% CI, 12.0-15.8) had exotropia. The esotropia:exotropia ratio was 5.4:1 (95% CI, 3.4:1 to 7.5:1). Age-specific incidence curves for congenital esotropia, fully accommodative esotropia, partially accommodative esotropia, and all exotropia revealed interactions between strabismus subtype and age, suggesting that the different subtypes had different age-specific patterns of incidence (P< .001 for all comparisons between pairs of curves). The median age at detection for the 4 subtypes was 0, 32.0, 26.1, and 16.6 months, respectively. CONCLUSIONS AND RELEVANCE: In a national, population-based cohort study, we found a cumulative incidence of strabismus consistent with those reported in smaller European and American cohorts, but a somewhat higher esotropia:exotropia ratio than those that, to our knowledge, are typically reported by English and American studies. Patterns of incidence by age differed for different strabismus subtypes, indicating differences in age at onset and thereby implying differences in the underlying etiology.

Original languageEnglish (US)
Pages (from-to)1047-1053
Number of pages7
JournalJAMA Ophthalmology
Volume135
Issue number10
DOIs
StatePublished - Oct 1 2017

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Esotropia
Strabismus
Exotropia
Incidence
Population
Cohort Studies
Parturition
Health Planning
Age Distribution
Denmark
Age of Onset
Health Services

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Torp-Pedersen, T., Boyd, H. A., Skotte, L., Haargaard, B., Wohlfahrt, J., Holmes, J. M., & Melbye, M. (2017). Strabismus incidence in a Danish population-based cohort of children. JAMA Ophthalmology, 135(10), 1047-1053. https://doi.org/10.1001/jamaophthalmol.2017.3158

Strabismus incidence in a Danish population-based cohort of children. / Torp-Pedersen, Tobias; Boyd, Heather A.; Skotte, Line; Haargaard, Birgitte; Wohlfahrt, Jan; Holmes, Jonathan M; Melbye, Mads.

In: JAMA Ophthalmology, Vol. 135, No. 10, 01.10.2017, p. 1047-1053.

Research output: Contribution to journalArticle

Torp-Pedersen, T, Boyd, HA, Skotte, L, Haargaard, B, Wohlfahrt, J, Holmes, JM & Melbye, M 2017, 'Strabismus incidence in a Danish population-based cohort of children', JAMA Ophthalmology, vol. 135, no. 10, pp. 1047-1053. https://doi.org/10.1001/jamaophthalmol.2017.3158
Torp-Pedersen T, Boyd HA, Skotte L, Haargaard B, Wohlfahrt J, Holmes JM et al. Strabismus incidence in a Danish population-based cohort of children. JAMA Ophthalmology. 2017 Oct 1;135(10):1047-1053. https://doi.org/10.1001/jamaophthalmol.2017.3158
Torp-Pedersen, Tobias ; Boyd, Heather A. ; Skotte, Line ; Haargaard, Birgitte ; Wohlfahrt, Jan ; Holmes, Jonathan M ; Melbye, Mads. / Strabismus incidence in a Danish population-based cohort of children. In: JAMA Ophthalmology. 2017 ; Vol. 135, No. 10. pp. 1047-1053.
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