Abstract
Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-70 |
| Number of pages | 10 |
| Journal | Mayo Clinic Proceedings |
| Volume | 91 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
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ASJC Scopus subject areas
- Medicine(all)
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Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People. / Redwood, Diana G.; Asay, Elvin D.; Blake, Ian D.; Sacco, Pamela E.; Christensen, Claudia M.; Sacco, Frank D.; Tiesinga, James J.; Devens, Mary E.; Alberts, Steven Robert; Mahoney, Douglas W.; Yab, Tracy C.; Foote, Patrick H.; Smyrk, Thomas Christopher; Provost, Ellen M.; Ahlquist, David A.
In: Mayo Clinic Proceedings, Vol. 91, No. 1, 01.01.2016, p. 61-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People
AU - Redwood, Diana G.
AU - Asay, Elvin D.
AU - Blake, Ian D.
AU - Sacco, Pamela E.
AU - Christensen, Claudia M.
AU - Sacco, Frank D.
AU - Tiesinga, James J.
AU - Devens, Mary E.
AU - Alberts, Steven Robert
AU - Mahoney, Douglas W.
AU - Yab, Tracy C.
AU - Foote, Patrick H.
AU - Smyrk, Thomas Christopher
AU - Provost, Ellen M.
AU - Ahlquist, David A.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P
AB - Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P
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UR - http://www.scopus.com/inward/citedby.url?scp=84952861843&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2015.10.008
DO - 10.1016/j.mayocp.2015.10.008
M3 - Article
C2 - 26520415
AN - SCOPUS:84952861843
VL - 91
SP - 61
EP - 70
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 1
ER -