Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People

Diana G. Redwood; Elvin D. Asay; Ian D. Blake; Pamela E. Sacco; Claudia M. Christensen; Frank D. Sacco; James J. Tiesinga; Mary E. Devens; Steven Robert Alberts; Douglas W. Mahoney; Tracy C. Yab; Patrick H. Foote; Thomas Christopher Smyrk; Ellen M. Provost; David A. Ahlquist

doi:10.1016/j.mayocp.2015.10.008

Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People

Diana G. Redwood, Elvin D. Asay, Ian D. Blake, Pamela E. Sacco, Claudia M. Christensen, Frank D. Sacco, James J. Tiesinga, Mary E. Devens, Steven Robert Alberts, Douglas W. Mahoney, Tracy C. Yab, Patrick H. Foote, Thomas Christopher Smyrk, Ellen M. Provost, David A. Ahlquist

Research output: Contribution to journal › Article

35 Scopus citations

Abstract

Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P

Original language	English (US)
Pages (from-to)	61-70
Number of pages	10
Journal	Mayo Clinic Proceedings
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/j.mayocp.2015.10.008
State	Published - Jan 1 2016

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.mayocp.2015.10.008

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Redwood, D. G., Asay, E. D., Blake, I. D., Sacco, P. E., Christensen, C. M., Sacco, F. D., Tiesinga, J. J., Devens, M. E., Alberts, S. R., Mahoney, D. W., Yab, T. C., Foote, P. H., Smyrk, T. C., Provost, E. M., & Ahlquist, D. A. (2016). Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People. Mayo Clinic Proceedings, 91(1), 61-70. https://doi.org/10.1016/j.mayocp.2015.10.008

Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People. / Redwood, Diana G.; Asay, Elvin D.; Blake, Ian D.; Sacco, Pamela E.; Christensen, Claudia M.; Sacco, Frank D.; Tiesinga, James J.; Devens, Mary E.; Alberts, Steven Robert; Mahoney, Douglas W.; Yab, Tracy C.; Foote, Patrick H.; Smyrk, Thomas Christopher; Provost, Ellen M.; Ahlquist, David A.

In: Mayo Clinic Proceedings, Vol. 91, No. 1, 01.01.2016, p. 61-70.

Research output: Contribution to journal › Article

Redwood, DG, Asay, ED, Blake, ID, Sacco, PE, Christensen, CM, Sacco, FD, Tiesinga, JJ, Devens, ME, Alberts, SR, Mahoney, DW, Yab, TC, Foote, PH, Smyrk, TC, Provost, EM & Ahlquist, DA 2016, 'Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People', Mayo Clinic Proceedings, vol. 91, no. 1, pp. 61-70. https://doi.org/10.1016/j.mayocp.2015.10.008

Redwood, Diana G. ; Asay, Elvin D. ; Blake, Ian D. ; Sacco, Pamela E. ; Christensen, Claudia M. ; Sacco, Frank D. ; Tiesinga, James J. ; Devens, Mary E. ; Alberts, Steven Robert ; Mahoney, Douglas W. ; Yab, Tracy C. ; Foote, Patrick H. ; Smyrk, Thomas Christopher ; Provost, Ellen M. ; Ahlquist, David A. / Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People. In: Mayo Clinic Proceedings. 2016 ; Vol. 91, No. 1. pp. 61-70.

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abstract = "Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P",

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AU - Christensen, Claudia M.

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AU - Tiesinga, James J.

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AB - Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for detection of screening-relevant colorectal neoplasia (SRN) in Alaska Native people, who have among the world's highest rates of colorectal cancer (CRC) and limited access to conventional screening approaches. Patients and Methods We performed a prospective, cross-sectional study of asymptomatic Alaska Native adults aged 40-85 years and older undergoing screening or surveillance colonoscopy between February 6, 2012, and August 7, 2014. Results Among 868 enrolled participants, 661 completed the study (403 [61%] women). Overall, SRN detection by MT-sDNA (49%) was superior to that by FIT (28%; P

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