Abstract
The results show that dibutyryl cyclic AMP stimulates tyrosine hydroxylase activity in an adrenergic clone of mouse neuroblastoma. This effect of dibutyryl cyclic AMP seems in part to be independent of its ability to slow cell division. Sodium butyrate, however, seems to increase tyrosine hydroxylase activity by inhibiting cell division. Prostaglandin PGE1 which has been reported to increase intracellular levels of cyclic AMP in clones of mouse neuroblastoma did not affect tyrosine hydroxylase activity to the same extent as dibutyryl cyclic AMP.
| Original language | English (US) |
|---|---|
| Title of host publication | NATURE NEW BIOL. |
| Pages | 175-177 |
| Number of pages | 3 |
| Volume | 242 |
| Edition | 119 |
| State | Published - 1973 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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Cite this
Richelson, E. (1973). Stimulation of tyrosine hydroxylase activity in an adrenergic clone of mouse neuroblastoma by dibutyryl cyclic AMP. In NATURE NEW BIOL. (119 ed., Vol. 242, pp. 175-177)