Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment

George L. Barnes, Sanjeev Kakar, Siddarth Vora, Elise F. Morgan, Louis C. Gerstenfeld, Thomas A. Einhorn

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Over the past several years, there has been an increasing interest in the biology of bone repair and potential technologies for enhancing fracture-healing. Part of this interest is derived from the growing age of the population and the recognition that increased age carries an increased risk of complications after fracture. Although use of locally implanted or injected growth factors has received the most attention, systemic treatments for the enhancement of bone repair, especially for situations in which bone repair may be diminished or delayed, are now under investigation. Since the approval of parathyroid hormone (PTH) as an anabolic treatment for osteoporosis, there has been an increasing interest in other potential clinical uses for this compound in musculoskeletal conditions. It is now widely recognized that PTH administration is an effective therapy to increase bone mineral density and prevent fractures in patients with osteoporosis. More recently, a growing body of evidence has supported the conclusion that PTH will also be an effective anabolic therapy for the enhancement of bone repair after fracture. This review focuses on the recent research demonstrating the potential of PTH in the management of bone repair in a number of fracture models and also highlights the ongoing studies into the mechanisms of PTH actions on endochondral bone repair.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalJournal of Bone and Joint Surgery - Series A
Volume90
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Fracture Healing
Parathyroid Hormone
Bone and Bones
Osteoporosis
Therapeutics
Bone Density
Intercellular Signaling Peptides and Proteins
Technology
Research
Population

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. / Barnes, George L.; Kakar, Sanjeev; Vora, Siddarth; Morgan, Elise F.; Gerstenfeld, Louis C.; Einhorn, Thomas A.

In: Journal of Bone and Joint Surgery - Series A, Vol. 90, No. SUPPL. 1, 02.2008, p. 120-127.

Research output: Contribution to journalArticle

Barnes, George L. ; Kakar, Sanjeev ; Vora, Siddarth ; Morgan, Elise F. ; Gerstenfeld, Louis C. ; Einhorn, Thomas A. / Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. In: Journal of Bone and Joint Surgery - Series A. 2008 ; Vol. 90, No. SUPPL. 1. pp. 120-127.
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