Stiffness and Beyond: What MR Elastography Can Tell Us About Brain Structure and Function Under Physiologic and Pathologic Conditions

Ziying Yin, Anthony J. Romano, Armando Manduca, Richard Lorne Ehman, John III Huston

Research output: Contribution to journalArticle

Abstract

Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to "palpate by imaging" and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.

Original languageEnglish (US)
Pages (from-to)305-318
Number of pages14
JournalTopics in magnetic resonance imaging : TMRI
Volume27
Issue number5
DOIs
StatePublished - Oct 1 2018

Fingerprint

Elasticity Imaging Techniques
Brain
Friction
Amyotrophic Lateral Sclerosis
Brain Diseases
Demyelinating Diseases
Viscosity
Neurodegenerative Diseases
Multiple Sclerosis
Dementia
Disease Progression
Inflammation
Research
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{9fdf4076626d4435a4641286fe0cf328,
title = "Stiffness and Beyond: What MR Elastography Can Tell Us About Brain Structure and Function Under Physiologic and Pathologic Conditions",
abstract = "Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to {"}palpate by imaging{"} and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.",
author = "Ziying Yin and Romano, {Anthony J.} and Armando Manduca and Ehman, {Richard Lorne} and Huston, {John III}",
year = "2018",
month = "10",
day = "1",
doi = "10.1097/RMR.0000000000000178",
language = "English (US)",
volume = "27",
pages = "305--318",
journal = "Topics in Magnetic Resonance Imaging",
issn = "0899-3459",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Stiffness and Beyond

T2 - What MR Elastography Can Tell Us About Brain Structure and Function Under Physiologic and Pathologic Conditions

AU - Yin, Ziying

AU - Romano, Anthony J.

AU - Manduca, Armando

AU - Ehman, Richard Lorne

AU - Huston, John III

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to "palpate by imaging" and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.

AB - Brain magnetic resonance elastography (MRE) was developed on the basis of a desire to "palpate by imaging" and is becoming a powerful tool in the investigation of neurophysiological and neuropathological states. Measurements are acquired with a specialized MR phase-contrast pulse sequence that can detect tissue motion in response to an applied external or internal excitation. The tissue viscoelasticity is then reconstructed from the measured displacement. Quantitative characterization of brain viscoelastic behaviors provides us an insight into the brain structure and function by assessing the mechanical rigidity, viscosity, friction, and connectivity of brain tissues. Changes in these features are associated with inflammation, demyelination, and neurodegeneration that contribute to brain disease onset and progression. Here, we review the basic principles and limitations of brain MRE and summarize its current neuroanatomical studies and clinical applications to the most common neurosurgical and neurodegenerative disorders, including intracranial tumors, dementia, multiple sclerosis, amyotrophic lateral sclerosis, and traumatic brain injury. Going forward, further improvement in acquisition techniques, stable inverse reconstruction algorithms, and advanced numerical, physical, and preclinical validation models is needed to increase the utility of brain MRE in both research and clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=85054457571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054457571&partnerID=8YFLogxK

U2 - 10.1097/RMR.0000000000000178

DO - 10.1097/RMR.0000000000000178

M3 - Article

C2 - 30289827

AN - SCOPUS:85054457571

VL - 27

SP - 305

EP - 318

JO - Topics in Magnetic Resonance Imaging

JF - Topics in Magnetic Resonance Imaging

SN - 0899-3459

IS - 5

ER -