Sterols and immune mechanisms in asthma

Rodney D. Britt, Ned Porter, Mitchell H. Grayson, Kymberly M. Gowdy, Megan Ballinger, Kara Wada, Hye Young Kim, Mireia Guerau-de-Arellano

Research output: Contribution to journalReview articlepeer-review

Abstract

The field of sterol and oxysterol biology in lung disease has recently gained attention, revealing a unique need for sterol uptake and metabolism in the lung. The presence of cholesterol transport, biosynthesis, and sterol/oxysterol-mediated signaling in immune cells suggests a role in immune regulation. In support of this idea, statin drugs that inhibit the cholesterol biosynthesis rate-limiting step enzyme, hydroxymethyl glutaryl coenzyme A reductase, show immunomodulatory activity in several models of inflammation. Studies in human asthma reveal contradicting results, whereas promising retrospective studies suggest benefits of statins in severe asthma. Here, we provide a timely review by discussing the role of sterols in immune responses in asthma, analytical tools to evaluate the role of sterols in disease, and potential mechanistic pathways and targets relevant to asthma. Our review reveals the importance of sterols in immune processes and highlights the need for further research to solve critical gaps in the field.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
DOIs
StateAccepted/In press - 2022

Keywords

  • asthma
  • cholesterol
  • immunology
  • oxysterol
  • Sterol

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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