Steroid-sparing regimens in organ transplantation

Dean Y. Kim, Mark D. Stegall

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Although corticosteroids have been a mainstay of immunosuppressive regimens for decades, their use has been associated with significant morbidity in transplant recipients. Several studies in liver transplant recipients suggest that steroid-sparing regimens are well tolerated immunologically and may reduce cardiovascular complications associated with their use. The safety and efficacy of steroid withdrawal in kidney, pancreas, and heart transplants are less clear. With the introduction of newer, potent immunosuppressive agents such as tacrolimus, mycophenolate mofetil, and sirolimus, steroid withdrawal is being tested more frequently in these organs. Recent data in clinical pancreatic islet transplantation even suggest that corticosteroids may be contraindicated in this type of transplant. This review covers the recent progress made in steroid-sparing regimens and some of the current controversies in islet and solid organ transplantation.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalCurrent opinion in organ transplantation
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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