Abstract
Although corticosteroids have been a mainstay of immunosuppressive regimens for decades, their use has been associated with significant morbidity in transplant recipients. Several studies in liver transplant recipients suggest that steroid-sparing regimens are well tolerated immunologically and may reduce cardiovascular complications associated with their use. The safety and efficacy of steroid withdrawal in kidney, pancreas, and heart transplants are less clear. With the introduction of newer, potent immunosuppressive agents such as tacrolimus, mycophenolate mofetil, and sirolimus, steroid withdrawal is being tested more frequently in these organs. Recent data in clinical pancreatic islet transplantation even suggest that corticosteroids may be contraindicated in this type of transplant. This review covers the recent progress made in steroid-sparing regimens and some of the current controversies in islet and solid organ transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-319 |
| Number of pages | 7 |
| Journal | Current Opinion in Organ Transplantation |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Steroid-sparing regimens in organ transplantation. / Kim, Dean Y.; Stegall, Mark D.
In: Current Opinion in Organ Transplantation, Vol. 6, No. 4, 2001, p. 313-319.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Steroid-sparing regimens in organ transplantation
AU - Kim, Dean Y.
AU - Stegall, Mark D
PY - 2001
Y1 - 2001
N2 - Although corticosteroids have been a mainstay of immunosuppressive regimens for decades, their use has been associated with significant morbidity in transplant recipients. Several studies in liver transplant recipients suggest that steroid-sparing regimens are well tolerated immunologically and may reduce cardiovascular complications associated with their use. The safety and efficacy of steroid withdrawal in kidney, pancreas, and heart transplants are less clear. With the introduction of newer, potent immunosuppressive agents such as tacrolimus, mycophenolate mofetil, and sirolimus, steroid withdrawal is being tested more frequently in these organs. Recent data in clinical pancreatic islet transplantation even suggest that corticosteroids may be contraindicated in this type of transplant. This review covers the recent progress made in steroid-sparing regimens and some of the current controversies in islet and solid organ transplantation.
AB - Although corticosteroids have been a mainstay of immunosuppressive regimens for decades, their use has been associated with significant morbidity in transplant recipients. Several studies in liver transplant recipients suggest that steroid-sparing regimens are well tolerated immunologically and may reduce cardiovascular complications associated with their use. The safety and efficacy of steroid withdrawal in kidney, pancreas, and heart transplants are less clear. With the introduction of newer, potent immunosuppressive agents such as tacrolimus, mycophenolate mofetil, and sirolimus, steroid withdrawal is being tested more frequently in these organs. Recent data in clinical pancreatic islet transplantation even suggest that corticosteroids may be contraindicated in this type of transplant. This review covers the recent progress made in steroid-sparing regimens and some of the current controversies in islet and solid organ transplantation.
UR - http://www.scopus.com/inward/record.url?scp=0035686978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035686978&partnerID=8YFLogxK
U2 - 10.1097/00075200-200112000-00008
DO - 10.1097/00075200-200112000-00008
M3 - Article
VL - 6
SP - 313
EP - 319
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
SN - 1087-2418
IS - 4
ER -