Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination

Don J. Mahad; Susan Staugaitis; Paul Ruggieri; Joseph Parisi; B. K. Kleinschmidt-Demasters; Hans Lassmann; Richard M. Ransohoff

doi:10.1016/j.jns.2004.08.015

Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination

Don J. Mahad, Susan Staugaitis, Paul Ruggieri, Joseph Parisi, B. K. Kleinschmidt-Demasters, Hans Lassmann, Richard M. Ransohoff

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid idsease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.

Original language	English (US)
Pages (from-to)	3-5
Number of pages	3
Journal	Journal of the neurological sciences
Volume	228
Issue number	1
DOIs	https://doi.org/10.1016/j.jns.2004.08.015
State	Published - Jan 15 2005

Keywords

Autoimmune
Demyelination
Encephalopathy
Steroid-responsive
Thyroiditis

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1016/j.jns.2004.08.015

Cite this

@article{272fdd180ba442aaad3c7c6541cb5e40,

title = "Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination",

abstract = "Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid idsease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.",

keywords = "Autoimmune, Demyelination, Encephalopathy, Steroid-responsive, Thyroiditis",

author = "Mahad, {Don J.} and Susan Staugaitis and Paul Ruggieri and Joseph Parisi and Kleinschmidt-Demasters, {B. K.} and Hans Lassmann and Ransohoff, {Richard M.}",

year = "2005",

month = jan,

day = "15",

doi = "10.1016/j.jns.2004.08.015",

language = "English (US)",

volume = "228",

pages = "3--5",

journal = "Journal of the neurological sciences",

issn = "0022-510X",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination

AU - Mahad, Don J.

AU - Staugaitis, Susan

AU - Ruggieri, Paul

AU - Parisi, Joseph

AU - Kleinschmidt-Demasters, B. K.

AU - Lassmann, Hans

AU - Ransohoff, Richard M.

PY - 2005/1/15

Y1 - 2005/1/15

N2 - Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid idsease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.

AB - Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid idsease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.

KW - Autoimmune

KW - Demyelination

KW - Encephalopathy

KW - Steroid-responsive

KW - Thyroiditis

UR - http://www.scopus.com/inward/record.url?scp=10644226731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10644226731&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2004.08.015

DO - 10.1016/j.jns.2004.08.015

M3 - Article

C2 - 15607202

AN - SCOPUS:10644226731

SN - 0022-510X

VL - 228

SP - 3

EP - 5

JO - Journal of the neurological sciences

JF - Journal of the neurological sciences

IS - 1

ER -

Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this