Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination

Don J. Mahad, Susan Staugaitis, Paul Ruggieri, Joseph Parisi, B. K. Kleinschmidt-Demasters, Hans Lassmann, Richard M. Ransohoff

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid idsease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalJournal of the neurological sciences
Volume228
Issue number1
DOIs
StatePublished - Jan 15 2005

Keywords

  • Autoimmune
  • Demyelination
  • Encephalopathy
  • Steroid-responsive
  • Thyroiditis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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