Steroid receptors and giant cell tumor of bone.

L. E. Wold, T. Spelsberg, N. Jiang, F. Sim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The cell of origin and giant cell tumor remains unknown, but on the basis of most experimental evidence it is probably a mesenchymal cell showing some macrophage characteristics. The clinical features which have led people to suggest that this tumor may be a steroid receptor positive lesion are tenuous at best. Early histochemical data suggesting a presence of estrogen and progesterone receptors in giant cell tumor have not been substantiated by further studies. Immunohistochemical techniques have not identified estrogen receptors in giant cell tumor. Multiple biochemical techniques have failed to identify clinically significant levels of estrogen or progesterone receptors in giant cell tumor.

Original languageEnglish (US)
Pages (from-to)153-164
Number of pages12
JournalCurrent topics in pathology
Volume80
StatePublished - 1989
Externally publishedYes

Fingerprint

Giant Cell Tumor of Bone
Giant Cell Tumors
Steroid Receptors
Estrogen Receptors
Progesterone Receptors
Macrophages
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wold, L. E., Spelsberg, T., Jiang, N., & Sim, F. (1989). Steroid receptors and giant cell tumor of bone. Current topics in pathology, 80, 153-164.

Steroid receptors and giant cell tumor of bone. / Wold, L. E.; Spelsberg, T.; Jiang, N.; Sim, F.

In: Current topics in pathology, Vol. 80, 1989, p. 153-164.

Research output: Contribution to journalArticle

Wold, LE, Spelsberg, T, Jiang, N & Sim, F 1989, 'Steroid receptors and giant cell tumor of bone.', Current topics in pathology, vol. 80, pp. 153-164.
Wold LE, Spelsberg T, Jiang N, Sim F. Steroid receptors and giant cell tumor of bone. Current topics in pathology. 1989;80:153-164.
Wold, L. E. ; Spelsberg, T. ; Jiang, N. ; Sim, F. / Steroid receptors and giant cell tumor of bone. In: Current topics in pathology. 1989 ; Vol. 80. pp. 153-164.
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