Steroid avoidance in renal transplantation

Amy Lightner, Waldo Concepcion, Paul Grimm

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose of Review: The recent surge in the use of steroid-avoidance protocols for pediatric renal transplant recipients has been fueled by the numerous adverse side effects of steroids and development of alternatives for successful immunosuppression. Steroid-avoidance protocols were first attempted in the adult population, and with positive outcomes, pediatrics soon followed. As more pediatric patients are placed on steroid-avoidance protocols, we must begin answering several important questions such as patient and graft outcome, safety profiles of various steroid-avoidance induction protocols, viral complications and incidence of transplant lymphoproliferative disease (PTLD), metabolic benefits, and the affect of steroid minimization on growth. Recent Findings: Initial results from steroid-avoidance protocols show these protocols are safe and effective with improved graft survival, metabolic profiles, and linear growth without an increase in viremia or PTLD. Summary: Although initial results are promising, there is still a lack of long-term data from large, prospective randomized trials, and there is not enough data to determine the optimal steroid-avoidance protocol for pediatric renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalCurrent opinion in organ transplantation
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2011

Keywords

  • Immunosuppression
  • pediatric renal transplantation
  • steroid avoidance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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