Stereotactic radiosurgery alone for one to two brain metastases from cancer of unknown primary

Liesa Dziggel, Amira Bajrovic, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background/Aim: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation. Patients and Methods: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival. Results: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%. Conclusion: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.

Original languageEnglish (US)
Pages (from-to)565-567
Number of pages3
JournalAnticancer research
Volume38
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Brain metastases
  • Cancer of unknown primary
  • Freedom from new cerebral lesions
  • Local control
  • Stereotactic radiosurgery
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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