Stem cell treatment for avascular necrosis of the femoral head: Current perspectives

Matthew T. Houdek, Cody C. Wyles, John R. Martin, Rafael J. Sierra

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Avascular necrosis (AVN) of the femoral head is a progressive disease that predominantly affects younger patients. Although the exact pathophysiology of AVN has yet to be elucidated, the disease is characterized by a vascular insult to the blood supply of the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes. If AVN is diagnosed in the early stages of the disease, it may be possible to attempt surgical procedures which preserve the hip joint, including decompression of the femoral head augmented with concentrated bone marrow. The use of autologous stem cells has shown promise in halting the progression of AVN of the femoral head, and subsequently preventing young patients from undergoing total hip arthroplasty. The purpose of this study was to review the current use of stem cells for the treatment of AVN of the femoral head.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalStem Cells and Cloning: Advances and Applications
Volume7
Issue number1
DOIs
StatePublished - Apr 9 2014

Keywords

  • Avascular necrosis
  • Concentrated bone marrow
  • Femoral head
  • Osteonecrosis
  • Stem cells

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Cell Biology

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