Stem cell transplantation: graft-mediated antileukemia effects.

William J. Hogan, Hans Joachim Deeg

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Graft-mediated antileukemia (GVL) activity is a major factor contributing to the success of allogeneic hematopoietic stem transplantation (aHCT). Recent advances have permitted the establishment of GVL activity without the need for a myeloablative conditioning regimen, thereby permitting even older and sicker patients to avail of potentially curative therapy. Use of adoptive immunotherapy by combining reduced intensity conditioning and donor leukocyte infusion (DLI) has resulted in strategies that can be exploited to maximize GVL effects while minimizing toxicity. These advances, combined with new molecularly targeted agents, creates new possibilities to develop less toxic, curative therapy for a greater number of patients. This review summarizes pertinent information regarding the evidence in favor of GVL effects, the impact of disease type and mechanisms of GVL.

Original languageEnglish (US)
Pages (from-to)421-444
Number of pages24
JournalMethods in molecular medicine
Volume109
StatePublished - 2005

ASJC Scopus subject areas

  • Molecular Medicine

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