TY - JOUR
T1 - Stem cell therapy and its potential role in pituitary disorders
AU - Lara-Velazquez, Montserrat
AU - Akinduro, Oluwaseun O.
AU - Reimer, Ronald
AU - Woodmansee, Whitney W.
AU - Quinones-Hinojosa, Alfredo
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Purpose of review The pituitary gland is one of the key components of the endocrine system. Congenital or acquired alterations can mediate destruction of cells in the gland leading to hormonal dysfunction. Even though pharmacological treatment for pituitary disorders is available, exogenous hormone replacement is neither curative nor sustainable. Thus, alternative therapies to optimize management and improve quality of life are desired. Recent findings An alternative modality to re-establish pituitary function is to promote endocrine cell regeneration through stem cells that can be obtained from the pituitary parenchyma or pluripotent cells. Stem cell therapy has been successfully applied to a plethora of other disorders, and is a promising alternative to hormonal supplementation for resumption of normal hormone homeostasis. Summary In this review, we describe the common causes for pituitary deficiencies and the advances in cellular therapy to restore the physiological pituitary function.
AB - Purpose of review The pituitary gland is one of the key components of the endocrine system. Congenital or acquired alterations can mediate destruction of cells in the gland leading to hormonal dysfunction. Even though pharmacological treatment for pituitary disorders is available, exogenous hormone replacement is neither curative nor sustainable. Thus, alternative therapies to optimize management and improve quality of life are desired. Recent findings An alternative modality to re-establish pituitary function is to promote endocrine cell regeneration through stem cells that can be obtained from the pituitary parenchyma or pluripotent cells. Stem cell therapy has been successfully applied to a plethora of other disorders, and is a promising alternative to hormonal supplementation for resumption of normal hormone homeostasis. Summary In this review, we describe the common causes for pituitary deficiencies and the advances in cellular therapy to restore the physiological pituitary function.
KW - hypopituitarism
KW - pituitary cellular restorative treatment
KW - pituitary deficiencies
KW - pituitary stem cells
KW - stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=85019632283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019632283&partnerID=8YFLogxK
U2 - 10.1097/MED.0000000000000346
DO - 10.1097/MED.0000000000000346
M3 - Review article
C2 - 28520591
AN - SCOPUS:85019632283
SN - 1752-296X
VL - 24
SP - 292
EP - 300
JO - Current Opinion in Endocrinology, Diabetes and Obesity
JF - Current Opinion in Endocrinology, Diabetes and Obesity
IS - 4
ER -