TY - JOUR
T1 - Stem Cell Therapies for Inflammatory Bowel Disease
AU - Lightner, Amy L.
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Purpose of Review: Stem cell therapies have demonstrated safety and efficacy in the treatment of perianal Crohn’s disease as compared to conventional therapy. Thus, an understanding of their place in the treatment algorithm for inflammatory bowel disease has become imperative as we move into an era of regenerative medicine. Recent Findings: There have now been over a dozen clinical trials highlighting stem cells as a useful therapeutic in Crohn’s disease. Due to the success in the local treatment for perianal Crohn’s disease, investigation is continuing in the space of targeted systemic delivery for the treatment of luminal disease. Summary: As we increase the number of patients treated in clinical trials, it is imperative to define the optimal cell donor, optimize treatment dosing and retreatment protocols, and understand methods for safely targeting and treating intraluminal disease.
AB - Purpose of Review: Stem cell therapies have demonstrated safety and efficacy in the treatment of perianal Crohn’s disease as compared to conventional therapy. Thus, an understanding of their place in the treatment algorithm for inflammatory bowel disease has become imperative as we move into an era of regenerative medicine. Recent Findings: There have now been over a dozen clinical trials highlighting stem cells as a useful therapeutic in Crohn’s disease. Due to the success in the local treatment for perianal Crohn’s disease, investigation is continuing in the space of targeted systemic delivery for the treatment of luminal disease. Summary: As we increase the number of patients treated in clinical trials, it is imperative to define the optimal cell donor, optimize treatment dosing and retreatment protocols, and understand methods for safely targeting and treating intraluminal disease.
KW - Luminal Crohn’s disease
KW - Mesenchymal stem cells
KW - Perianal Crohn’s disease
KW - Regenerative medicine
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85064005702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064005702&partnerID=8YFLogxK
U2 - 10.1007/s11894-019-0672-y
DO - 10.1007/s11894-019-0672-y
M3 - Review article
C2 - 30955111
AN - SCOPUS:85064005702
SN - 1522-8037
VL - 21
JO - Current gastroenterology reports
JF - Current gastroenterology reports
IS - 4
M1 - 16
ER -