Stem cell-derived extracellular vesicles for renal repair: do cardiovascular comorbidities matter?

Research output: Contribution to journalArticle

Abstract

Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.

Original languageEnglish (US)
Pages (from-to)F1414-F1419
JournalAmerican journal of physiology. Renal physiology
Volume317
Issue number6
DOIs
StatePublished - Dec 1 2019

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Mesenchymal Stromal Cells
Chronic Renal Insufficiency
Comorbidity
Stem Cells
Kidney
Kidney Diseases
Nuclear Family
Cardiovascular Diseases
Obesity
Hypertension
Extracellular Vesicles
Therapeutics

Keywords

  • chronic kidney disease
  • extracellular vesicles
  • mesenchymal stem cells
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

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abstract = "Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.",
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AB - Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.

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