TY - JOUR
T1 - Stem cell-derived extracellular vesicles for renal repair
T2 - Do cardiovascular comorbidities matter?
AU - Eirin, Alfonso
AU - Lerman, Lilach O.
N1 - Funding Information:
L. O. Lerman received grant funding from Novo Nordisk and is an advisor to Weijian Technologies. No conflicts of interest, financial or otherwise, are declared by the author(s).
Funding Information:
This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grants DK-106427, DK-122137, DK-104273, DK-120292, and DK-102325.
Publisher Copyright:
1931-857X/19 Copyright © 2019 the American Physiological Society.
PY - 2019
Y1 - 2019
N2 - Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.
AB - Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.
KW - Chronic kidney disease
KW - Extracellular vesicles
KW - Mesenchymal stem cells
KW - Metabolic syndrome
KW - Obesity
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U2 - 10.1152/ajprenal.00434.2019
DO - 10.1152/ajprenal.00434.2019
M3 - Review article
C2 - 31630544
AN - SCOPUS:85075960836
SN - 0363-6127
VL - 317
SP - F1414-F1419
JO - American journal of physiology. Renal physiology
JF - American journal of physiology. Renal physiology
IS - 6
ER -