Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain

Benjamin Brinkmann, David T Jones, Squire Matthew Stead, Noojan Kazemi, Terence J. O'Brien, Elson L. So, Hal Blumenfeld, Brian P. Mullan, Gregory Alan Worrell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.

Original languageEnglish (US)
Pages (from-to)190-198
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Oximes
Nervous System Diseases
Single-Photon Emission-Computed Tomography
Amines
Brain
Functional Laterality
Cerebrum
Frontal Lobe
Healthy Volunteers
Perfusion
propylene
Population
Therapeutics

Keywords

  • brain asymmetry
  • brain imaging
  • SPECT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain. / Brinkmann, Benjamin; Jones, David T; Stead, Squire Matthew; Kazemi, Noojan; O'Brien, Terence J.; So, Elson L.; Blumenfeld, Hal; Mullan, Brian P.; Worrell, Gregory Alan.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 1, 01.2012, p. 190-198.

Research output: Contribution to journalArticle

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