Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults

Richard B. Kennedy; Pritish K. Tosh; Krista M. Goergen; Diane E. Grill; Ann L. Oberg; Gregory A. Poland

doi:10.1016/j.vaccine.2015.06.031

Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults

Richard B. Kennedy, Pritish K. Tosh, Krista M. Goergen, Diane E. Grill, Ann L. Oberg, Gregory A. Poland

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.

Original language	English (US)
Pages (from-to)	3682-3688
Number of pages	7
Journal	Vaccine
Volume	33
Issue number	31
DOIs	https://doi.org/10.1016/j.vaccine.2015.06.031
State	Published - Jul 17 2015

Keywords

Adult
Age factors
Aged
Immunity, Humoral
Influenza vaccines
Models, Statistical

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2015.06.031

Cite this

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title = "Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults",

abstract = "Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.",

keywords = "Adult, Age factors, Aged, Immunity, Humoral, Influenza vaccines, Models, Statistical",

author = "Kennedy, {Richard B.} and Tosh, {Pritish K.} and Goergen, {Krista M.} and Grill, {Diane E.} and Oberg, {Ann L.} and Poland, {Gregory A.}",

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AU - Kennedy, Richard B.

AU - Tosh, Pritish K.

AU - Goergen, Krista M.

AU - Grill, Diane E.

AU - Oberg, Ann L.

AU - Poland, Gregory A.

PY - 2015/7/17

Y1 - 2015/7/17

N2 - Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.

AB - Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.

KW - Adult

KW - Age factors

KW - Aged

KW - Immunity, Humoral

KW - Influenza vaccines

KW - Models, Statistical

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Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults

Abstract

Keywords

ASJC Scopus subject areas

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