Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults

Richard B Kennedy, Pritish K. Tosh, Krista M. Goergen, Diane E. Grill, Ann L Oberg, Gregory A. Poland

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.

Original languageEnglish (US)
Pages (from-to)3682-3688
Number of pages7
JournalVaccine
Volume33
Issue number31
DOIs
StatePublished - Jul 17 2015

Fingerprint

Enzyme-Linked Immunospot Assay
Influenza Vaccines
Hemagglutination
Innate Immunity
humoral immunity
influenza
B-Lymphocytes
seroconversion
hemagglutination
vaccines
Inactivated Vaccines
B-lymphocytes
Insurance Benefits
Humoral Immunity
Chemokines
Human Influenza
Public Health
chemokines
Cytokines
neutralization

Keywords

  • Adult
  • Age factors
  • Aged
  • Immunity, Humoral
  • Influenza vaccines
  • Models, Statistical

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults. / Kennedy, Richard B; Tosh, Pritish K.; Goergen, Krista M.; Grill, Diane E.; Oberg, Ann L; Poland, Gregory A.

In: Vaccine, Vol. 33, No. 31, 17.07.2015, p. 3682-3688.

Research output: Contribution to journalArticle

Kennedy, Richard B ; Tosh, Pritish K. ; Goergen, Krista M. ; Grill, Diane E. ; Oberg, Ann L ; Poland, Gregory A. / Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults. In: Vaccine. 2015 ; Vol. 33, No. 31. pp. 3682-3688.
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