Statistical modeling using early markers of innate immunity to explain variation in humoral responses to influenza vaccine in older adults

Richard B. Kennedy, Pritish K. Tosh, Krista M. Goergen, Diane E. Grill, Ann L. Oberg, Gregory A. Poland

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.

Original languageEnglish (US)
Pages (from-to)3682-3688
Number of pages7
JournalVaccine
Volume33
Issue number31
DOIs
StatePublished - Jul 17 2015

Keywords

  • Adult
  • Age factors
  • Aged
  • Immunity, Humoral
  • Influenza vaccines
  • Models, Statistical

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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