TY - JOUR
T1 - Statins use and risk of depression
T2 - A systematic review and meta-analysis
AU - Parsaik, Ajay K.
AU - Singh, Balwinder
AU - Hassan Murad, M.
AU - Singh, Kuljit
AU - Mascarenhas, Soniya S.
AU - Williams, Mark D.
AU - Lapid, Maria I.
AU - Richardson, Jarrett W.
AU - West, Colin P.
AU - Rummans, Teresa A.
N1 - Funding Information:
This work was supported by CTSA grant UL1 TR000135 from the National Center for Advancing Translational Sciences , a component of the National Institutes of Health (NIH) . The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/5
Y1 - 2014/5
N2 - Importance Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. Objective To determine whether statin use is associated with depression and to evaluate the evidence supporting this association. Data sources Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, EMBASE, PsycInfo, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus were searched through December 28, 2012. Study selection We included studies that evaluated exposure to statins, reported the development of depression, and relative risks or odds ratios (ORs) or provided data for their estimation. Two reviewers screened 981 abstracts independently using a standardized form, reviewed full text of 59 selected articles, and included 7 studies in this metaanalysis. Data extraction and synthesis Study design, statin exposure, development of depression, and study quality were extracted by 2 independent reviewers. A pooled OR with 95% confidence interval (CI) was estimated using the random-effects model and heterogeneity was assessed using Cochran's Q test and the I2 statistic. Results Seven observational studies (4 cohort, 2 nested case-control, and 1 cross-sectional) from 5 countries enrolling 9187 patients were included. Statin users were 32% less likely to develop depression than nonusers (adjusted OR, 0.68; 95% CI, 0.52-0.89). Modest heterogeneity was observed between the studies (I 2=55%, P=0.01), which could be accounted for by one study, exclusion of which removed the heterogeneity (P=0.40, I2=2%) and further strengthened the antidepressant effect of statin (adjusted OR, 0.63; 95% CI, 0.43-0.93). Heterogeneity could not be explained by study design or study population. The quality of supporting evidence was fair. Conclusions and relevance This systematic review and meta-analysis suggests that statin use is associated with lower risk for depression. However, higher-quality studies are needed to confirm the magnitude of this association.
AB - Importance Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. Objective To determine whether statin use is associated with depression and to evaluate the evidence supporting this association. Data sources Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, EMBASE, PsycInfo, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus were searched through December 28, 2012. Study selection We included studies that evaluated exposure to statins, reported the development of depression, and relative risks or odds ratios (ORs) or provided data for their estimation. Two reviewers screened 981 abstracts independently using a standardized form, reviewed full text of 59 selected articles, and included 7 studies in this metaanalysis. Data extraction and synthesis Study design, statin exposure, development of depression, and study quality were extracted by 2 independent reviewers. A pooled OR with 95% confidence interval (CI) was estimated using the random-effects model and heterogeneity was assessed using Cochran's Q test and the I2 statistic. Results Seven observational studies (4 cohort, 2 nested case-control, and 1 cross-sectional) from 5 countries enrolling 9187 patients were included. Statin users were 32% less likely to develop depression than nonusers (adjusted OR, 0.68; 95% CI, 0.52-0.89). Modest heterogeneity was observed between the studies (I 2=55%, P=0.01), which could be accounted for by one study, exclusion of which removed the heterogeneity (P=0.40, I2=2%) and further strengthened the antidepressant effect of statin (adjusted OR, 0.63; 95% CI, 0.43-0.93). Heterogeneity could not be explained by study design or study population. The quality of supporting evidence was fair. Conclusions and relevance This systematic review and meta-analysis suggests that statin use is associated with lower risk for depression. However, higher-quality studies are needed to confirm the magnitude of this association.
KW - Depression
KW - Meta-analysis
KW - Statins
KW - Systematic review
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U2 - 10.1016/j.jad.2013.11.026
DO - 10.1016/j.jad.2013.11.026
M3 - Review article
C2 - 24370264
AN - SCOPUS:84898597546
SN - 0165-0327
VL - 160
SP - 62
EP - 67
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -