Statin Use and Incident Cataract Surgery: A Case-Control Study

Jay C. Erie, Matthew R. Pueringer, Scott M. Brue, Alanna Chamberlain, David O. Hodge

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To determine the association between statin use and incident cataract surgery.Methods: Using the resources of the Rochester Epidemiology Project, a retrospective population-based, case-control study was performed. Cases included 6024 county residents aged 50 years and older who had first-eye cataract surgery between 1 January 2004 and 31 December 2011. Controls included residents who had never had cataract surgery and were matched to cases by age, sex, and index date within 1 month of surgery. Statin medications continuously prescribed for at least 1 year before the surgery date (cases) or index date (controls) were examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models.Results: There were 2557 (42%) statin users among cases having cataract surgery compared to 2038 (34%) statin users among controls never having had cataract surgery (p < 0.0001). Incident cataract surgery was significantly associated with increased odds of statin use (OR 1.29, 95% CI 1.19-1.55) after adjusting for age, sex, diabetes, cardiovascular disease, cerebrovascular disease, peripheral vascular disease, renal disease, oral and inhaled steroid use, and selective serotonin reuptake inhibitor use. The association was consistent in both subgroups of women (OR 1.34, 95%CI 1.22-1.49) and men (OR 1.17, 95% CI 1.05-1.30).Conclusions: Incident cataract surgery was associated with increased odds of statin use, and underscores the possibility that increasing statin use could be contributing to rising rates of cataract surgery.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalOphthalmic Epidemiology
Volume23
Issue number1
DOIs
StatePublished - Jan 2 2016

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cataract
Case-Control Studies
Odds Ratio
Confidence Intervals
Logistic Models
Cerebrovascular Disorders
Peripheral Vascular Diseases
Serotonin Uptake Inhibitors
Epidemiology
Cardiovascular Diseases
Steroids
Kidney

Keywords

  • Cataract surgery
  • epidemiology
  • populationbased
  • Rochester Epidemiology Project
  • statins

ASJC Scopus subject areas

  • Epidemiology
  • Ophthalmology

Cite this

Statin Use and Incident Cataract Surgery : A Case-Control Study. / Erie, Jay C.; Pueringer, Matthew R.; Brue, Scott M.; Chamberlain, Alanna; Hodge, David O.

In: Ophthalmic Epidemiology, Vol. 23, No. 1, 02.01.2016, p. 40-45.

Research output: Contribution to journalArticle

Erie, Jay C. ; Pueringer, Matthew R. ; Brue, Scott M. ; Chamberlain, Alanna ; Hodge, David O. / Statin Use and Incident Cataract Surgery : A Case-Control Study. In: Ophthalmic Epidemiology. 2016 ; Vol. 23, No. 1. pp. 40-45.
@article{3304e9a6290745f78b363e8f4bc10cb9,
title = "Statin Use and Incident Cataract Surgery: A Case-Control Study",
abstract = "Purpose: To determine the association between statin use and incident cataract surgery.Methods: Using the resources of the Rochester Epidemiology Project, a retrospective population-based, case-control study was performed. Cases included 6024 county residents aged 50 years and older who had first-eye cataract surgery between 1 January 2004 and 31 December 2011. Controls included residents who had never had cataract surgery and were matched to cases by age, sex, and index date within 1 month of surgery. Statin medications continuously prescribed for at least 1 year before the surgery date (cases) or index date (controls) were examined. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using logistic regression models.Results: There were 2557 (42{\%}) statin users among cases having cataract surgery compared to 2038 (34{\%}) statin users among controls never having had cataract surgery (p < 0.0001). Incident cataract surgery was significantly associated with increased odds of statin use (OR 1.29, 95{\%} CI 1.19-1.55) after adjusting for age, sex, diabetes, cardiovascular disease, cerebrovascular disease, peripheral vascular disease, renal disease, oral and inhaled steroid use, and selective serotonin reuptake inhibitor use. The association was consistent in both subgroups of women (OR 1.34, 95{\%}CI 1.22-1.49) and men (OR 1.17, 95{\%} CI 1.05-1.30).Conclusions: Incident cataract surgery was associated with increased odds of statin use, and underscores the possibility that increasing statin use could be contributing to rising rates of cataract surgery.",
keywords = "Cataract surgery, epidemiology, populationbased, Rochester Epidemiology Project, statins",
author = "Erie, {Jay C.} and Pueringer, {Matthew R.} and Brue, {Scott M.} and Alanna Chamberlain and Hodge, {David O.}",
year = "2016",
month = "1",
day = "2",
doi = "10.3109/09286586.2015.1077258",
language = "English (US)",
volume = "23",
pages = "40--45",
journal = "Ophthalmic Epidemiology",
issn = "0928-6586",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Statin Use and Incident Cataract Surgery

T2 - A Case-Control Study

AU - Erie, Jay C.

AU - Pueringer, Matthew R.

AU - Brue, Scott M.

AU - Chamberlain, Alanna

AU - Hodge, David O.

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Purpose: To determine the association between statin use and incident cataract surgery.Methods: Using the resources of the Rochester Epidemiology Project, a retrospective population-based, case-control study was performed. Cases included 6024 county residents aged 50 years and older who had first-eye cataract surgery between 1 January 2004 and 31 December 2011. Controls included residents who had never had cataract surgery and were matched to cases by age, sex, and index date within 1 month of surgery. Statin medications continuously prescribed for at least 1 year before the surgery date (cases) or index date (controls) were examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models.Results: There were 2557 (42%) statin users among cases having cataract surgery compared to 2038 (34%) statin users among controls never having had cataract surgery (p < 0.0001). Incident cataract surgery was significantly associated with increased odds of statin use (OR 1.29, 95% CI 1.19-1.55) after adjusting for age, sex, diabetes, cardiovascular disease, cerebrovascular disease, peripheral vascular disease, renal disease, oral and inhaled steroid use, and selective serotonin reuptake inhibitor use. The association was consistent in both subgroups of women (OR 1.34, 95%CI 1.22-1.49) and men (OR 1.17, 95% CI 1.05-1.30).Conclusions: Incident cataract surgery was associated with increased odds of statin use, and underscores the possibility that increasing statin use could be contributing to rising rates of cataract surgery.

AB - Purpose: To determine the association between statin use and incident cataract surgery.Methods: Using the resources of the Rochester Epidemiology Project, a retrospective population-based, case-control study was performed. Cases included 6024 county residents aged 50 years and older who had first-eye cataract surgery between 1 January 2004 and 31 December 2011. Controls included residents who had never had cataract surgery and were matched to cases by age, sex, and index date within 1 month of surgery. Statin medications continuously prescribed for at least 1 year before the surgery date (cases) or index date (controls) were examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models.Results: There were 2557 (42%) statin users among cases having cataract surgery compared to 2038 (34%) statin users among controls never having had cataract surgery (p < 0.0001). Incident cataract surgery was significantly associated with increased odds of statin use (OR 1.29, 95% CI 1.19-1.55) after adjusting for age, sex, diabetes, cardiovascular disease, cerebrovascular disease, peripheral vascular disease, renal disease, oral and inhaled steroid use, and selective serotonin reuptake inhibitor use. The association was consistent in both subgroups of women (OR 1.34, 95%CI 1.22-1.49) and men (OR 1.17, 95% CI 1.05-1.30).Conclusions: Incident cataract surgery was associated with increased odds of statin use, and underscores the possibility that increasing statin use could be contributing to rising rates of cataract surgery.

KW - Cataract surgery

KW - epidemiology

KW - populationbased

KW - Rochester Epidemiology Project

KW - statins

UR - http://www.scopus.com/inward/record.url?scp=84958846157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958846157&partnerID=8YFLogxK

U2 - 10.3109/09286586.2015.1077258

DO - 10.3109/09286586.2015.1077258

M3 - Article

C2 - 26766069

AN - SCOPUS:84958846157

VL - 23

SP - 40

EP - 45

JO - Ophthalmic Epidemiology

JF - Ophthalmic Epidemiology

SN - 0928-6586

IS - 1

ER -