Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients

Salil V. Deo, Abeer Rababa'h, Salah E. Altarabsheh, Ju Yong Lim, Yang Hyun Cho, Soon J. Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I2=41%; p-value for heterogeneity=0.13}.

Original languageEnglish (US)
Pages (from-to)985-987
Number of pages3
JournalHeart Lung and Circulation
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiomyopathies
Survival
Heart Failure
Therapeutics
Dilated Cardiomyopathy
Meta-Analysis
Randomized Controlled Trials
Mortality
Pharmaceutical Preparations

Keywords

  • Dilated cardiomyopathy
  • Heart failure
  • HydroxylglutarylCoA reductase inhibitiors
  • Non-ischemic cardiomyopathy
  • Statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Statin therapy improves long-term survival in non-ischaemic cardiomyopathy : A pooled analysis of 4500 patients. / Deo, Salil V.; Rababa'h, Abeer; Altarabsheh, Salah E.; Lim, Ju Yong; Cho, Yang Hyun; Park, Soon J.

In: Heart Lung and Circulation, Vol. 23, No. 10, 01.10.2014, p. 985-987.

Research output: Contribution to journalArticle

Deo, Salil V. ; Rababa'h, Abeer ; Altarabsheh, Salah E. ; Lim, Ju Yong ; Cho, Yang Hyun ; Park, Soon J. / Statin therapy improves long-term survival in non-ischaemic cardiomyopathy : A pooled analysis of 4500 patients. In: Heart Lung and Circulation. 2014 ; Vol. 23, No. 10. pp. 985-987.
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