Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients

Salil V. Deo, Abeer Rababa'h, Salah E. Altarabsheh, Ju Yong Lim, Yang Hyun Cho, Soon J. Park

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I2=41%; p-value for heterogeneity=0.13}.

Original languageEnglish (US)
Pages (from-to)985-987
Number of pages3
JournalHeart Lung and Circulation
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Dilated cardiomyopathy
  • Heart failure
  • HydroxylglutarylCoA reductase inhibitiors
  • Non-ischemic cardiomyopathy
  • Statin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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