Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury

Daryl J. Kor, Remzi Iscimen, Murat Yilmaz, Michael J. Brown, Daniel R. Brown, Ognjen Gajic

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Purpose: Preclinical studies suggest that HMG-CoA reductase inhibitors (statins) may attenuate organ dysfunction. We evaluated whether statins are associated with attenuation of lung injury and prevention of associated organ failure in patients with ALI/ARDS. Methods: From a database of patients with ALI/ARDS, we determined the presence and timing of statin administration. Main outcome measures were the development and progression of pulmonary and nonpulmonary organ failures as assessed by changes in PaO2/FiO 2 ratio and Sequential Organ Failure Assessment score (SOFA) between days 1 and 7 after the onset of ALI/ARDS. Secondary outcomes included ventilator free days, ICU and hospital mortality, and lengths of ICU and hospital stay. Results: From 178 patients with ALI/ARDS, 45 (25%) received statin therapy. From day 1 to day 7, the statin group showed less improvement in their PaO 2/FiO2 ratio (27 vs. 55, P = 0.042). Ventilator free days (median 21 vs. 16 days, P = 0.158), development or progression of organ failures (median ΔSOFA 1 vs. 2, P = 0.275), ICU mortality (20% vs. 23%, P = 0.643), and hospital mortality (27 vs. 37%, P = 0.207) were not significantly different in the statin and non-statin groups. After adjustment for baseline characteristics and propensity for statin administration, there were no differences in ICU or hospital lengths of stay. Conclusion: In this retrospective cohort study, statin use was not associated with improved outcome in patients with ALI/ARDS. We were unable to find evidence for protection against pulmonary or nonpulmonary organ dysfunction.

Original languageEnglish (US)
Pages (from-to)1039-1046
Number of pages8
JournalIntensive Care Medicine
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2009

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • HMG-CoA reductase inhibitors
  • Multi-organ failure
  • Statins

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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