TY - JOUR
T1 - Static lung-lung interactions in unilateral emphysema
AU - Margulies, S. S.
AU - Schriner, R. W.
AU - Schroeder, M. A.
AU - Hubmayr, R. D.
PY - 1992
Y1 - 1992
N2 - Motivated by the introduction of single-lung transplantation into clinical practice, we compared the static mechanical properties of the respiratory system in six supine dogs before (at baseline) with those after the induction of unilateral emphysema. Relaxation volume (Vrel), total lung capacity (TLC), and static compliance of the emphysematous lung increased to 214 ± 68, 186 ± 39, and 253 ± 95% (SD) of baseline, respectively. Vrel of the nonemphysematous lung fell to 81 ± 28% of baseline, with no significant change in TLC of the nonemphysematous lung or its pressure-volume relationship, indicating that unilateral hyperinflation does not cause dropout of contralateral lung units. After unilateral emphysema, the chest wall shifted to a higher unstressed or neutral volume (when pleural pressure equals atmospheric pressure) in three of six animals, minimizing the anticipated decrease in lung recoil pressure at the higher respiratory system Vrel. The pattern of relative lung emptying in the intact dog and in the excised lungs was similar during stepwise deflations from TLC, suggesting that mean pleural pressure of the hemithoraces is equal. We conclude that in the dog the static volume distribution between emphysematous and nonemphysematous lungs is determined only by differences in lung recoil and compliance.
AB - Motivated by the introduction of single-lung transplantation into clinical practice, we compared the static mechanical properties of the respiratory system in six supine dogs before (at baseline) with those after the induction of unilateral emphysema. Relaxation volume (Vrel), total lung capacity (TLC), and static compliance of the emphysematous lung increased to 214 ± 68, 186 ± 39, and 253 ± 95% (SD) of baseline, respectively. Vrel of the nonemphysematous lung fell to 81 ± 28% of baseline, with no significant change in TLC of the nonemphysematous lung or its pressure-volume relationship, indicating that unilateral hyperinflation does not cause dropout of contralateral lung units. After unilateral emphysema, the chest wall shifted to a higher unstressed or neutral volume (when pleural pressure equals atmospheric pressure) in three of six animals, minimizing the anticipated decrease in lung recoil pressure at the higher respiratory system Vrel. The pattern of relative lung emptying in the intact dog and in the excised lungs was similar during stepwise deflations from TLC, suggesting that mean pleural pressure of the hemithoraces is equal. We conclude that in the dog the static volume distribution between emphysematous and nonemphysematous lungs is determined only by differences in lung recoil and compliance.
KW - chest wall adaptation
KW - single-lung transplantation
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U2 - 10.1152/jappl.1992.73.2.545
DO - 10.1152/jappl.1992.73.2.545
M3 - Article
C2 - 1399979
AN - SCOPUS:0026666075
SN - 0161-7567
VL - 73
SP - 545
EP - 551
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 2
ER -