TY - JOUR
T1 - State of the art in the endoscopic imaging and ablation of Barrett's esophagus
AU - Panossian, Abraham M.
AU - Raimondo, Massimo
AU - Wolfsen, Herbert C.
PY - 2011/5
Y1 - 2011/5
N2 - Barrett's esophagus is the result of long-term acid reflux and is a precursor to esophageal adenocarcinoma. Surgical resection of the esophagus has been the mainstay of treatment for high grade dysplasia and early cancer. However, recent advances in the endoscopic imaging and ablation technologies have made esophagectomy avoidable in patients with dysplasia and superficial neoplasia. In this article, we review the most relevant endoscopic imaging technologies, such as chromoendoscopy, narrow band and autofluorescence imaging, and confocal laser endomicroscopy. We also review the various endoscopic ablation technologies, such as endoscopic mucosal resection, photodynamic therapy, radiofrequency ablation, and cryotherapy. Finally, we focus on the studies that evaluate the efficacy of these imaging and ablation technologies in finding and eradicating neoplastic Barrett's esophagus.
AB - Barrett's esophagus is the result of long-term acid reflux and is a precursor to esophageal adenocarcinoma. Surgical resection of the esophagus has been the mainstay of treatment for high grade dysplasia and early cancer. However, recent advances in the endoscopic imaging and ablation technologies have made esophagectomy avoidable in patients with dysplasia and superficial neoplasia. In this article, we review the most relevant endoscopic imaging technologies, such as chromoendoscopy, narrow band and autofluorescence imaging, and confocal laser endomicroscopy. We also review the various endoscopic ablation technologies, such as endoscopic mucosal resection, photodynamic therapy, radiofrequency ablation, and cryotherapy. Finally, we focus on the studies that evaluate the efficacy of these imaging and ablation technologies in finding and eradicating neoplastic Barrett's esophagus.
KW - Ablation
KW - Barrett's esophagus
KW - Dysplasia
KW - Endoscopic imaging
KW - Mucosal resection
UR - http://www.scopus.com/inward/record.url?scp=79953271442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953271442&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2011.01.011
DO - 10.1016/j.dld.2011.01.011
M3 - Review article
C2 - 21330224
AN - SCOPUS:79953271442
SN - 1590-8658
VL - 43
SP - 365
EP - 373
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 5
ER -