TY - JOUR
T1 - Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
AU - Teglund, Stephan
AU - McKay, Catriona
AU - Schuetz, Erin
AU - Van Deursen, Jan M.
AU - Stravopodis, Dimitrios
AU - Wang, Demin
AU - Brown, Michael
AU - Bodner, Sara
AU - Grosveld, Gerard
AU - Ihle, James N.
N1 - Funding Information:
The authors would like to thank Linda Snyder for her excellent technical assistance in conducting the studies. This work was supported, in part, by Cancer Center CORE grant CA21765, by grant RO1 DK42932 to J. N. I., by grant PO1 HL53749 to J. N. I., by grant RO1 ES08658 to E. S., and by the American Lebanese Syrian Associated Charities (ALSAC).
PY - 1998/5/29
Y1 - 1998/5/29
N2 - A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected.
AB - A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected.
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U2 - 10.1016/S0092-8674(00)81444-0
DO - 10.1016/S0092-8674(00)81444-0
M3 - Article
C2 - 9630227
AN - SCOPUS:0000943469
VL - 93
SP - 841
EP - 850
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -