Abstract
Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain functions associated with cytokines such as erythropoietin. Here, we demonstrate that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergo cell cycle progression or to express genes controlling cell cycle progression. In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor β chain-deficient mice. These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-259 |
| Number of pages | 11 |
| Journal | Immunity |
| Volume | 10 |
| Issue number | 2 |
| State | Published - Feb 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. / Moriggl, Richard; Topham, David J.; Teglund, Stephan; Sexl, Veronika; McKay, Catriona; Wang, Demin; Hoffmeyer, Angelika; Van Deursen, Jan; Sangster, Mark Y.; Bunting, Kevin D.; Grosveld, Gerard C.; Ihle, James N.
In: Immunity, Vol. 10, No. 2, 02.1999, p. 249-259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
AU - Moriggl, Richard
AU - Topham, David J.
AU - Teglund, Stephan
AU - Sexl, Veronika
AU - McKay, Catriona
AU - Wang, Demin
AU - Hoffmeyer, Angelika
AU - Van Deursen, Jan
AU - Sangster, Mark Y.
AU - Bunting, Kevin D.
AU - Grosveld, Gerard C.
AU - Ihle, James N.
PY - 1999/2
Y1 - 1999/2
N2 - Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain functions associated with cytokines such as erythropoietin. Here, we demonstrate that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergo cell cycle progression or to express genes controlling cell cycle progression. In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor β chain-deficient mice. These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells.
AB - Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain functions associated with cytokines such as erythropoietin. Here, we demonstrate that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergo cell cycle progression or to express genes controlling cell cycle progression. In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor β chain-deficient mice. These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells.
UR - http://www.scopus.com/inward/record.url?scp=0033082138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033082138&partnerID=8YFLogxK
M3 - Article
C2 - 10072077
AN - SCOPUS:0033082138
VL - 10
SP - 249
EP - 259
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 2
ER -