@article{9ecb7049bd984dfb9f83ee6fe7731a83,
title = "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells",
abstract = "Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain functions associated with cytokines such as erythropoietin. Here, we demonstrate that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergo cell cycle progression or to express genes controlling cell cycle progression. In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor β chain-deficient mice. These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells.",
author = "Richard Moriggl and Topham, {David J.} and Stephan Teglund and Veronika Sexl and Catriona McKay and Demin Wang and Angelika Hoffmeyer and {Van Deursen}, Jan and Sangster, {Mark Y.} and Bunting, {Kevin D.} and Grosveld, {Gerard C.} and Ihle, {James N.}",
note = "Funding Information: The authors would like to thank Lynda Snyder, Kristen Rothammer, and Suzette Wingo for their excellent technical assistance. We would also like to thank Charles Sherr for providing monoclonal antibodies against cyclin D2 and D3, antisera against p27 and Cdk2 and baculovirus produced p27, the cyclins D2, D3, E, and A, and the kinases Cdk2, Cdk4, and Cdk6 that were used for controls. We would also like to thank Richard Ashmun, Richard Cross, Sam Lucas, Mahnaz Paktinat, and Ed Wingfield for FACS analysis. V. S. was a fellow supported by the Austrian Fond zur F{\"o}rderung der Wissenschaftlichen Forschung (FWF). This work was supported in part by Cancer Center CORE Grant CA21765, by grant RO1 DK42932 to J. N. I., by grant P01 HL53749, and by the American Lebanese Syrian Associated Charities (ALSAC). ",
year = "1999",
month = feb,
doi = "10.1016/S1074-7613(00)80025-4",
language = "English (US)",
volume = "10",
pages = "249--259",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",
}