Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Richard Moriggl, David J. Topham, Stephan Teglund, Veronika Sexl, Catriona McKay, Demin Wang, Angelika Hoffmeyer, Jan Van Deursen, Mark Y. Sangster, Kevin D. Bunting, Gerard C. Grosveld, James N. Ihle

Research output: Contribution to journalArticle

451 Citations (Scopus)

Abstract

Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain functions associated with cytokines such as erythropoietin. Here, we demonstrate that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergo cell cycle progression or to express genes controlling cell cycle progression. In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor β chain-deficient mice. These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells.

Original languageEnglish (US)
Pages (from-to)249-259
Number of pages11
JournalImmunity
Volume10
Issue number2
StatePublished - Feb 1999
Externally publishedYes

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Interleukin-2
Cell Cycle
T-Lymphocytes
Phenotype
Cytokines
cdc Genes
Interleukin-2 Receptors
Splenomegaly
Erythropoietin
Natural Killer Cells
Prolactin
Growth Hormone
Proteins
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Moriggl, R., Topham, D. J., Teglund, S., Sexl, V., McKay, C., Wang, D., ... Ihle, J. N. (1999). Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity, 10(2), 249-259.

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. / Moriggl, Richard; Topham, David J.; Teglund, Stephan; Sexl, Veronika; McKay, Catriona; Wang, Demin; Hoffmeyer, Angelika; Van Deursen, Jan; Sangster, Mark Y.; Bunting, Kevin D.; Grosveld, Gerard C.; Ihle, James N.

In: Immunity, Vol. 10, No. 2, 02.1999, p. 249-259.

Research output: Contribution to journalArticle

Moriggl, R, Topham, DJ, Teglund, S, Sexl, V, McKay, C, Wang, D, Hoffmeyer, A, Van Deursen, J, Sangster, MY, Bunting, KD, Grosveld, GC & Ihle, JN 1999, 'Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells', Immunity, vol. 10, no. 2, pp. 249-259.
Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 1999 Feb;10(2):249-259.
Moriggl, Richard ; Topham, David J. ; Teglund, Stephan ; Sexl, Veronika ; McKay, Catriona ; Wang, Demin ; Hoffmeyer, Angelika ; Van Deursen, Jan ; Sangster, Mark Y. ; Bunting, Kevin D. ; Grosveld, Gerard C. ; Ihle, James N. / Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. In: Immunity. 1999 ; Vol. 10, No. 2. pp. 249-259.
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