Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention

Claudia M. Brandt, William W. Sistrunk, Mary C. Duffy, Arlen D. Hanssen, James M. Steckelberg, Duane M. Ilstrup, Douglas R. Osmon

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Debridement and retention of the prosthesis was the initial treatment modality in 30 patients with 33 Staphylococcus aureus prosthetic joint infections (PJIs) who presented to the Mayo Clinic between 1980 and 1991. Treatment failure, defined as relapse of S. aureus PJI or occurrence of culture-negative PJI during continuous antistaphylococcal therapy, occurred in 21 of 33 prosthetic joints. The 1-year and 2-year cumulative probabilities of treatment failure were 54% (95% confidence interval [CI], 36%-71%) and 69% (95% CI, 52%-86%), respectively. A median of 4 additional surgical procedures (range, 1-9) were required to control the infection in the 21 prosthetic joints for which treatment failed. Prostheses that were debrided >2 days after onset of symptoms were associated with a higher probability of treatment failure than were those debrided within 2 days of onset (relative risk, 4.2; 95% CI, 1.6-10.3). These data suggest that debridement and retention of the prosthesis as the initial therapy for PJI due to S. aureus is associated with a high cumulative probability of treatment failure and that the probability of treatment failure may be related to the duration of symptoms.

Original languageEnglish (US)
Pages (from-to)914-919
Number of pages6
JournalClinical Infectious Diseases
Volume24
Issue number5
StatePublished - 1997

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Prosthesis Retention
Debridement
Staphylococcus aureus
Treatment Failure
Joints
Infection
Confidence Intervals
Therapeutics
Infection Control
Prostheses and Implants
Recurrence

ASJC Scopus subject areas

  • Immunology

Cite this

Brandt, C. M., Sistrunk, W. W., Duffy, M. C., Hanssen, A. D., Steckelberg, J. M., Ilstrup, D. M., & Osmon, D. R. (1997). Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clinical Infectious Diseases, 24(5), 914-919.

Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. / Brandt, Claudia M.; Sistrunk, William W.; Duffy, Mary C.; Hanssen, Arlen D.; Steckelberg, James M.; Ilstrup, Duane M.; Osmon, Douglas R.

In: Clinical Infectious Diseases, Vol. 24, No. 5, 1997, p. 914-919.

Research output: Contribution to journalArticle

Brandt, CM, Sistrunk, WW, Duffy, MC, Hanssen, AD, Steckelberg, JM, Ilstrup, DM & Osmon, DR 1997, 'Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention', Clinical Infectious Diseases, vol. 24, no. 5, pp. 914-919.
Brandt CM, Sistrunk WW, Duffy MC, Hanssen AD, Steckelberg JM, Ilstrup DM et al. Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clinical Infectious Diseases. 1997;24(5):914-919.
Brandt, Claudia M. ; Sistrunk, William W. ; Duffy, Mary C. ; Hanssen, Arlen D. ; Steckelberg, James M. ; Ilstrup, Duane M. ; Osmon, Douglas R. / Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. In: Clinical Infectious Diseases. 1997 ; Vol. 24, No. 5. pp. 914-919.
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