Standardizing drug adverse event reporting data

Liwei Wang, Guoqian D Jiang, Dingcheng Li, Hongfang D Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Normalizing data in the Adverse Event Reporting System (AERS), an FDA database, would improve the mining capacity of AERS for drug safety signal detection. In this study, we aim to normalize AERS and build a publicly available normalized Adverse drug events (ADE) data source.he drug information in AERS is normalized to RxNorm, a standard terminology source for medication. Drug class information is then obtained from the National Drug File-Reference Terminology (NDF-RT). Adverse drug events (ADE) are aggregated through mapping with the PT (Preferred Term) and SOC (System Organ Class) codes of MedDRA. Our study yields an aggregated knowledge-enhanced AERS data mining set (AERS-DM). The AERS-DM could provide more perspectives to mine AERS database for drug safety signal detection and could be used by research community in the data mining field.

Original languageEnglish (US)
Title of host publicationStudies in Health Technology and Informatics
Pages1101
Number of pages1
Volume192
Edition1-2
DOIs
StatePublished - 2013
Event14th World Congress on Medical and Health Informatics, MEDINFO 2013 - Copenhagen, Denmark
Duration: Aug 20 2013Aug 23 2013

Other

Other14th World Congress on Medical and Health Informatics, MEDINFO 2013
CountryDenmark
CityCopenhagen
Period8/20/138/23/13

Fingerprint

Signal detection
Terminology
Drug-Related Side Effects and Adverse Reactions
Data mining
Research Design
Data Mining
RxNorm
Pharmaceutical Preparations
Pharmaceutical Databases
Safety
Information Storage and Retrieval
Databases
Research

Keywords

  • Adverse drug events
  • adverse event reporting system (AERS)
  • data mining
  • data normalization
  • knowledge discovery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Wang, L., Jiang, G. D., Li, D., & Liu, H. D. (2013). Standardizing drug adverse event reporting data. In Studies in Health Technology and Informatics (1-2 ed., Vol. 192, pp. 1101) https://doi.org/10.3233/978-1-61499-289-9-1101

Standardizing drug adverse event reporting data. / Wang, Liwei; Jiang, Guoqian D; Li, Dingcheng; Liu, Hongfang D.

Studies in Health Technology and Informatics. Vol. 192 1-2. ed. 2013. p. 1101.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, L, Jiang, GD, Li, D & Liu, HD 2013, Standardizing drug adverse event reporting data. in Studies in Health Technology and Informatics. 1-2 edn, vol. 192, pp. 1101, 14th World Congress on Medical and Health Informatics, MEDINFO 2013, Copenhagen, Denmark, 8/20/13. https://doi.org/10.3233/978-1-61499-289-9-1101
Wang L, Jiang GD, Li D, Liu HD. Standardizing drug adverse event reporting data. In Studies in Health Technology and Informatics. 1-2 ed. Vol. 192. 2013. p. 1101 https://doi.org/10.3233/978-1-61499-289-9-1101
Wang, Liwei ; Jiang, Guoqian D ; Li, Dingcheng ; Liu, Hongfang D. / Standardizing drug adverse event reporting data. Studies in Health Technology and Informatics. Vol. 192 1-2. ed. 2013. pp. 1101
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