Standardized Added Metabolic Activity Predicts Survival after Intra-arterial Resin-Based 90Y Radioembolization Therapy in Unresectable Chemorefractory Metastatic Colorectal Cancer to the Liver

Faramarz Edalat, Juan C. Camacho, Nima Kokabi, Ayse T. Kendi, James R. Galt, Hyun S. Kim

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose Standardized added metabolic (SAM) activity is a functional objective measurement of the total tumoral metabolic activity that avoids partial volume effect and thresholding, which limit conventional PET parameters. The purpose of this study is to investigate the role of SAM in predicting survival in unresectable, chemorefractory colorectal hepatic metastatic disease treated with resin-based 90Y radioembolization. Materials and Methods This is a prospective correlative study of patients with unresectable, chemorefractory colorectal liver metastasis who underwent 18F-FDG PET/CT and CT/MRI before and after 90Y. Target RECIST, PERCIST, change in total glycolytic activity (ΔTGA), and ΔSAM treatment response were assessed. Percentage changes in diameter, SUVpeak, TGA, and SAM were calculated pre-and post-90Y therapy and objective response was defined as >30% change (responders). Survival analysis by Kaplan-Meier, log-rank, and Cox proportional hazard models were performed and significance was set at <0.05. Results Sixteen patients (mean age of 61.6) were enrolled and performed a total of 20 90Y therapies. After 90Y, target ΔSAM showed an objective response rate of 40% vs. 35%, 30%, and 22.2% based on target ΔTGA, PERCIST, and RECIST criteria, respectively. Median overall survival (OS) of the cohort after 90Y was 9.2 months (CI 95% 2.2-16.2). Patients demonstrating objective response based on ΔSAM had a median OS of 22.7 months (CI 95% 12.4-33.0) vs. 6.7 (CI 95% 4.2-9.2) in non-responders (P = 0.007). On multivariate analysis, hazard ratios for the objective response group based on target ΔSAM were 0.01 (P = 0.03) vs. 0.05 (P = 0.08), 0.20 (P = 0.29), and 0.91 (P = 0.98) based on target ΔTGA, PERCIST, and RECIST criteria, respectively. Conclusions In unresectable colorectal liver metastatic disease refractory to standard chemotherapy, ΔSAM predicted OS for assessment of response following 90Y radioembolization therapy, whereas RECIST, PERCIST, and ΔTGA did not.

Original languageEnglish (US)
Pages (from-to)e76-e81
JournalClinical nuclear medicine
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • PET
  • Y radioembolization
  • colorectal cancer
  • standardized added metabolic activity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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