Squamous cell carcinoma of the vulva stage IA: Long-term results

Javier F. Magrina, Jesus Gonzalez-Bosquet, Amy L. Weaver, Thomas A. Gaffey, Kevin O. Leslie, Maurice J. Webb, Karl C. Podratz

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9%). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7%) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7%, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.

Original languageEnglish (US)
Pages (from-to)24-27
Number of pages4
JournalGynecologic Oncology
Volume76
Issue number1
DOIs
StatePublished - Jan 2000

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Vulva
Squamous Cell Carcinoma
Groin
Recurrence
Neoplasm Metastasis
Lymph Node Excision
Dissection
Lymph Nodes
Guidelines

Keywords

  • Squamous cancer
  • Stage IA
  • Vulvar carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Magrina, J. F., Gonzalez-Bosquet, J., Weaver, A. L., Gaffey, T. A., Leslie, K. O., Webb, M. J., & Podratz, K. C. (2000). Squamous cell carcinoma of the vulva stage IA: Long-term results. Gynecologic Oncology, 76(1), 24-27. https://doi.org/10.1006/gyno.1999.5638

Squamous cell carcinoma of the vulva stage IA : Long-term results. / Magrina, Javier F.; Gonzalez-Bosquet, Jesus; Weaver, Amy L.; Gaffey, Thomas A.; Leslie, Kevin O.; Webb, Maurice J.; Podratz, Karl C.

In: Gynecologic Oncology, Vol. 76, No. 1, 01.2000, p. 24-27.

Research output: Contribution to journalArticle

Magrina, JF, Gonzalez-Bosquet, J, Weaver, AL, Gaffey, TA, Leslie, KO, Webb, MJ & Podratz, KC 2000, 'Squamous cell carcinoma of the vulva stage IA: Long-term results', Gynecologic Oncology, vol. 76, no. 1, pp. 24-27. https://doi.org/10.1006/gyno.1999.5638
Magrina JF, Gonzalez-Bosquet J, Weaver AL, Gaffey TA, Leslie KO, Webb MJ et al. Squamous cell carcinoma of the vulva stage IA: Long-term results. Gynecologic Oncology. 2000 Jan;76(1):24-27. https://doi.org/10.1006/gyno.1999.5638
Magrina, Javier F. ; Gonzalez-Bosquet, Jesus ; Weaver, Amy L. ; Gaffey, Thomas A. ; Leslie, Kevin O. ; Webb, Maurice J. ; Podratz, Karl C. / Squamous cell carcinoma of the vulva stage IA : Long-term results. In: Gynecologic Oncology. 2000 ; Vol. 76, No. 1. pp. 24-27.
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abstract = "Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9{\%}). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7{\%}) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7{\%}, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.",
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