Spontaneous regression of vestibular schwannomas after resection of contralateral tumor in neurofibromatosis type 2: Report of 2 cases

Kajetan L. Von Eckardstein, Charles W. Beatty, Colin L.W. Driscoll, Michael J. Link

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The authors report on 2 patients with bilateral vestibular schwannomas (VSs) who underwent unilateral surgical tumor removal. One patient was followed up for 4 years, the other for 9; in both cases, the contralateral VS regressed markedly without any additional treatment during the follow-up period. Serial MR imaging was performed to monitor the untreated tumor, which in both cases involved the only hearing ear. The tumors were assessed volumetrically. The contralateral tumors appeared to enlarge mildly at initial follow-up and then, with no treatment, regressed (to 23% of the original maximum volume in Case 1 and to 15% of the original maximum in Case 2). The largest posterior fossa diameter decreased from 30.1 mm to 18.6 mm in Case 1 over 4 years and from 27 mm to 16 mm over 8 years in Case 2. Hearing declined only mildly during follow-up in both patients. These cases demonstrate the first well-documented, long-term, spontaneous VS regressions in patients with neurofibromatosis Type 2. They underline the importance of careful observation of VS involving the only hearing ear in the management of bilateral VS to determine the natural growth pattern of the tumors. The mechanism of the dramatic spontaneous tumor regression is uncertain.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalJournal of neurosurgery
Volume112
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Natural history
  • Neurofibromatosis type 2
  • Tumor regression
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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