Spontaneous recovery from Friend retrovirus-induced leukemia: Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC

M. Miyazawa, J. Nishio, K. Wehrly, C. S. David, B. Chesebro

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Abstract

The Rfv-2 gene that influences the rate of spontaneous recovery from erythroleukemia induced by a low dose of Friend retrovirus complex was mapped to the Q/TL region of mouse MHC. Rfv-2 was physically and functionally distinct from the I-A-linked Ir gene that has been shown to control the responsiveness of Th cells to the envelope glycoprotein of Friend murine leukemia helper virus. The negative effect of the Rfv-2(s) allele was overcome by the B10.D2-H-2(dm1) mutation of the D-L genes of H-2, suggesting functional similarities between the D-L and Q/TL genes in influencing resistance against Friend murine leukemia retrovirus complex infection or possible modification of Q/TL expression by genes in the D-L region.

Original languageEnglish (US)
Pages (from-to)1964-1967
Number of pages4
JournalJournal of Immunology
Volume148
Issue number6
StatePublished - Jan 1 1992

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Miyazawa, M., Nishio, J., Wehrly, K., David, C. S., & Chesebro, B. (1992). Spontaneous recovery from Friend retrovirus-induced leukemia: Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC. Journal of Immunology, 148(6), 1964-1967.