Abstract
The Rfv-2 gene that influences the rate of spontaneous recovery from erythroleukemia induced by a low dose of Friend retrovirus complex was mapped to the Q/TL region of mouse MHC. Rfv-2 was physically and functionally distinct from the I-A-linked Ir gene that has been shown to control the responsiveness of Th cells to the envelope glycoprotein of Friend murine leukemia helper virus. The negative effect of the Rfv-2s allele was overcome by the B10.D2-H-2dm1 mutation of the D-L genes of H-2, suggesting functional similarities between the D-L and 9/TL genes in influencing resistance against Friend murine leukemia retrovirus complex infection or possible modification of Q/TL expression by genes in the D-L region.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1964-1967 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 148 |
| Issue number | 6 |
| State | Published - Mar 15 1992 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology