Spontaneous polymerization of the antibiotic peptide magainin 2

Raul Urrutia, Ricardo A. Cruciani, Jeffery L. Barker, Bechara Kachar

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalFEBS Letters
Volume247
Issue number1
DOIs
StatePublished - Apr 10 1989

Keywords

  • Antibiotic mechanism
  • Electron microscopy
  • Magainin 2
  • Polymerization

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Urrutia, R., Cruciani, R. A., Barker, J. L., & Kachar, B. (1989). Spontaneous polymerization of the antibiotic peptide magainin 2. FEBS Letters, 247(1), 17-21. https://doi.org/10.1016/0014-5793(89)81230-X