Spontaneous polymerization of the antibiotic peptide magainin 2

Raul Urrutia, Ricardo A. Cruciani, Jeffery L. Barker, Bechara Kachar

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalFEBS Letters
Volume247
Issue number1
DOIs
StatePublished - Apr 10 1989
Externally publishedYes

Fingerprint

Magainins
Polymerization
Anti-Bacterial Agents
Peptides
Ionic strength
Osmolar Concentration
Membranes

Keywords

  • Antibiotic mechanism
  • Electron microscopy
  • Magainin 2
  • Polymerization

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Urrutia, R., Cruciani, R. A., Barker, J. L., & Kachar, B. (1989). Spontaneous polymerization of the antibiotic peptide magainin 2. FEBS Letters, 247(1), 17-21. https://doi.org/10.1016/0014-5793(89)81230-X

Spontaneous polymerization of the antibiotic peptide magainin 2. / Urrutia, Raul; Cruciani, Ricardo A.; Barker, Jeffery L.; Kachar, Bechara.

In: FEBS Letters, Vol. 247, No. 1, 10.04.1989, p. 17-21.

Research output: Contribution to journalArticle

Urrutia, R, Cruciani, RA, Barker, JL & Kachar, B 1989, 'Spontaneous polymerization of the antibiotic peptide magainin 2', FEBS Letters, vol. 247, no. 1, pp. 17-21. https://doi.org/10.1016/0014-5793(89)81230-X
Urrutia, Raul ; Cruciani, Ricardo A. ; Barker, Jeffery L. ; Kachar, Bechara. / Spontaneous polymerization of the antibiotic peptide magainin 2. In: FEBS Letters. 1989 ; Vol. 247, No. 1. pp. 17-21.
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