Spontaneous polymerization of the antibiotic peptide magainin 2

Raul Urrutia; Ricardo A. Cruciani; Jeffery L. Barker; Bechara Kachar

doi:10.1016/0014-5793(89)81230-X

Spontaneous polymerization of the antibiotic peptide magainin 2

Raul Urrutia, Ricardo A. Cruciani, Jeffery L. Barker, Bechara Kachar

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	FEBS Letters
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(89)81230-X
State	Published - Apr 10 1989

Keywords

Antibiotic mechanism
Electron microscopy
Magainin 2
Polymerization

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(89)81230-X

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abstract = "We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.",

keywords = "Antibiotic mechanism, Electron microscopy, Magainin 2, Polymerization",

author = "Raul Urrutia and Cruciani, {Ricardo A.} and Barker, {Jeffery L.} and Bechara Kachar",

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AU - Urrutia, Raul

AU - Cruciani, Ricardo A.

AU - Barker, Jeffery L.

AU - Kachar, Bechara

PY - 1989/4/10

Y1 - 1989/4/10

N2 - We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

AB - We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

KW - Antibiotic mechanism

KW - Electron microscopy

KW - Magainin 2

KW - Polymerization

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Spontaneous polymerization of the antibiotic peptide magainin 2

Abstract

Keywords

ASJC Scopus subject areas

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