Spontaneous pneumomediastinum in a patient with bronchiolitis obliterans after bone marrow transplantation

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22 Scopus citations


After allogeneic bone marrow transplantation for chronic myelogenous leukemia, spontaneous pneumomediastinum and subcutaneous emphysema developed in a patient with bronchiolitis obliterans. Computed tomography scanning of the chest failed to reveal the cause. There was no evidence of a pulmonary process, pneumothorax, or pharyngeal or upper airway leak. Despite the alarming appearance of the patient, conservative management, including high-flow oxygen, resulted in resolution of the pneumomediastinum and subcutaneous emphysema. The cause of pneumomediastinum and subcutaneous emphysema in bone marrow transplant recipients is discussed.

Original languageEnglish (US)
Pages (from-to)695-696
Number of pages2
JournalBone Marrow Transplantation
Issue number8
StatePublished - Oct 2 1997



  • Bone marrow transplantation
  • Bronchiolitis obliterans
  • Graft-versus-host disease
  • Pneumomediastinum
  • Subcutaneous emphysema

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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