Spontaneous pneumomediastinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic bone marrow transplantation - Case report and review of literature

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Chronic graft-versus-host disease occurring in the setting of allogeneic bone marrow transplantation (BMT) can affect many organ systems, is a cause of significant morbidity, and contributes to late deaths. Bronchiolitis obliterans is a form of obstructive airway disease; when seen in the post-BMT setting, it is considered a manifestation of chronic graft-versus-host disease. Air-leak syndromes including pneumothoraces, pneumomediastinum and subcutaneous emphysema are rare complications of bronchiolitis obliterans. Here we describe a patient who developed pneumomediastinum, pneumopericardium, subcutaneous emphysema and pneumothorax secondary to severe bronchiolitis obliterans complicating the post bone marrow transplantation course.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalAnnals of hematology
Issue number7
StatePublished - Aug 20 2001



  • Bone marrow transplantation
  • Graft-versus-host disease
  • Pneumomediastinum
  • Pneumopericardium
  • Subcutaneous emphysema

ASJC Scopus subject areas

  • Hematology

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