TY - JOUR
T1 - Spontaneous pneumomediastinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic bone marrow transplantation - Case report and review of literature
AU - Kumar, S.
AU - Tefferi, A.
PY - 2001
Y1 - 2001
N2 - Chronic graft-versus-host disease occurring in the setting of allogeneic bone marrow transplantation (BMT) can affect many organ systems, is a cause of significant morbidity, and contributes to late deaths. Bronchiolitis obliterans is a form of obstructive airway disease; when seen in the post-BMT setting, it is considered a manifestation of chronic graft-versus-host disease. Air-leak syndromes including pneumothoraces, pneumomediastinum and subcutaneous emphysema are rare complications of bronchiolitis obliterans. Here we describe a patient who developed pneumomediastinum, pneumopericardium, subcutaneous emphysema and pneumothorax secondary to severe bronchiolitis obliterans complicating the post bone marrow transplantation course.
AB - Chronic graft-versus-host disease occurring in the setting of allogeneic bone marrow transplantation (BMT) can affect many organ systems, is a cause of significant morbidity, and contributes to late deaths. Bronchiolitis obliterans is a form of obstructive airway disease; when seen in the post-BMT setting, it is considered a manifestation of chronic graft-versus-host disease. Air-leak syndromes including pneumothoraces, pneumomediastinum and subcutaneous emphysema are rare complications of bronchiolitis obliterans. Here we describe a patient who developed pneumomediastinum, pneumopericardium, subcutaneous emphysema and pneumothorax secondary to severe bronchiolitis obliterans complicating the post bone marrow transplantation course.
KW - Bone marrow transplantation
KW - Graft-versus-host disease
KW - Pneumomediastinum
KW - Pneumopericardium
KW - Subcutaneous emphysema
UR - http://www.scopus.com/inward/record.url?scp=0034906770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034906770&partnerID=8YFLogxK
U2 - 10.1007/s002770100301
DO - 10.1007/s002770100301
M3 - Article
C2 - 11529471
AN - SCOPUS:0034906770
SN - 0939-5555
VL - 80
SP - 430
EP - 435
JO - Annals of hematology
JF - Annals of hematology
IS - 7
ER -