Spontaneous intracerebral hemorrhage due to coagulation disorders.

Alfredo Quinones-Hinojosa, Mittul Gulati, Vineeta Singh, Michael T. Lawton

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Although intracranial hemorrhage accounts for approximately 10 to 15% of all cases of stroke, it is associated with a high mortality rate. Bleeding disorders account for a small but significant risk factor associated with intracranial hemorrhage. In conditions such as hemophilia and acute leukemia associated with thrombocytopenia, massive intracranial hemorrhage is often the cause of death. The authors present a comprehensive review of both the physiology of hemostasis and the pathophysiology underlying spontaneous ICH due to coagulation disorders. These disorders are divided into acquired conditions, including iatrogenic and neoplastic coagulopathies, and congenital problems, including hemophilia and rarer diseases. The authors also discuss clinical features, diagnosis, and management of intracranial hemorrhage resulting from these bleeding disorders.

Original languageEnglish (US)
Pages (from-to)E3
JournalNeurosurgical focus
Volume15
Issue number4
DOIs
StatePublished - Oct 15 2003

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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