Spontaneous intracerebral hemorrhage

Maria I. Aguilar, W. David Freeman

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Spontaneous intracerebral hemorrhage (sICH) is defined as bleeding within the brain parenchyma, and occurs twice as commonly as subarachnoid hemorrhage, but is equally as deadly. Risk factors for sICH include hypertension, advanced age, leukoaraiosis, prior ICH, renal failure, use of anticoagulant drugs, and cerebral amyloid angiopathy. When a patient is clinically suspected of having sICH, head computed tomography scan is the standard diagnostic tool. However, newer magnetic resonance neuroimaging techniques may aid in determining the underlying pathology and aid in prognosis. Supportive care and blood pressure management are important in the care of patients with sICH. Ongoing research is aimed at determining a safe blood pressure goal that may also prevent expansion of hemorrhage. Hemostatic medications and neuroprotectants have thus far not shown clinical improvement. Although several neurosurgical trials have failed to demonstrate benefit for surgical evacuation of sICH, multiple research trials are ongoing investigating acute blood pressure control, deep or basal ganglionic hemorrhage evacuation via minimally invasive approach (MISTIE; http://mistietrial.com/default.aspx), lobar ICH evacuation (STICH; II http://research.ncl.ac.uk/stich/), and intraventricular thrombolysis with tissue plasminogen activator (tPA) (CLEAR III; http://biosgroup-johnshopkinsmedicine. health.officelive.com/default.aspx).

Original languageEnglish (US)
Pages (from-to)555-564
Number of pages10
JournalSeminars in Neurology
Volume30
Issue number5
DOIs
StatePublished - 2010

Fingerprint

Cerebral Hemorrhage
Blood Pressure
Basal Ganglia Hemorrhage
Leukoaraiosis
Research
Cerebral Amyloid Angiopathy
Hemorrhage
Neuroprotective Agents
Tissue Plasminogen Activator
Hemostatics
Subarachnoid Hemorrhage
Neuroimaging
Anticoagulants
Renal Insufficiency
Patient Care
Magnetic Resonance Spectroscopy
Head
Tomography
Pathology
Hypertension

Keywords

  • brain hemorrhage
  • Intracerebral hemorrhage
  • intracranial hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Spontaneous intracerebral hemorrhage. / Aguilar, Maria I.; Freeman, W. David.

In: Seminars in Neurology, Vol. 30, No. 5, 2010, p. 555-564.

Research output: Contribution to journalArticle

Aguilar, MI & Freeman, WD 2010, 'Spontaneous intracerebral hemorrhage', Seminars in Neurology, vol. 30, no. 5, pp. 555-564. https://doi.org/10.1055/s-0030-1268865
Aguilar, Maria I. ; Freeman, W. David. / Spontaneous intracerebral hemorrhage. In: Seminars in Neurology. 2010 ; Vol. 30, No. 5. pp. 555-564.
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