Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking ß2-microglobulin: A model of human spondyloarthropathies

Sanjay D. Khare, Harvinder S. Luthra, Chella S. David

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193 Scopus citations


Human class I major histocompatibility complex allele HLA-B27 is associated with a group of human diseases called "spondyloarthropathies." Studies on transgenic rats expressing HLA-B27 and human 132-microglobulin have confirmed the role of HLA-B27 in disease pathogenesis. Here we report spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking ß2- microglobulin (B27+ß2m-/−). In the absence of ß2-microglobulin, B27+ß2m -/- animals do not express the HLA-B27 transgene on the cell surface and have a very low level of CD8 + T cells. Most of the B27+ß2m-/− male mice showed nail changes, hair loss, and swelling in paws, which leads to ankylosis. The symptoms occur only after the B27+ß2m-/− mice are transferred from the specific pathogen-free mouse colony. These results suggest that aberrant assembly, transport, and expression of the HLA-B27 molecule may predispose an individual for development of the disease when exposed to an appropriate environmental trigger.

Original languageEnglish (US)
Pages (from-to)1153-1158
Number of pages6
JournalJournal of Experimental Medicine
Issue number4
StatePublished - Oct 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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