Spontaneous coronary artery dissection: Revascularization versus conservative therapy

Marysia S. Tweet, Mackram F. Eleid, Patricia J.M. Best, Ryan J. Lennon, Amir Lerman, Charanjit S. Rihal, David R. Holmes, Sharonne N. Hayes, Rajiv Gulati

Research output: Contribution to journalArticle

234 Scopus citations

Abstract

Background-Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic acute coronary syndrome for which optimal management remains undefined. Methods and Results-We performed a retrospective study of 189 patients presenting with a first SCAD episode. We evaluated outcomes according to initial management: (1) revascularization versus conservative therapy and (2) percutaneous coronary intervention (PCI) versus conservative therapy stratified by vessel flow at presentation. Demographics were similar in revascularization versus conservative (mean age, 44±9 years; women 92% both groups), but vessel occlusion was more frequent in revascularization (44/95 versus 18/94). There was 1 in-hospital death (revascularization) and 1 late death (conservative). Procedural failure rate was 53% in those managed with PCI. In the subgroup of patients presenting with preserved vessel flow, rates of PCI failure were similarly high (50%), and 6 (13%) required emergency coronary artery bypass grafting. In the conservative group, 85 of 94 (90%) had an uneventful in-hospital course, but 9 (10%) experienced early SCAD progression requiring revascularization. Kaplan-Meier estimated 5-year rates of target vessel revascularization and recurrent SCAD were no different in revascularization versus conservative therapy (30% versus 19%; P=0.06 and 23% versus 31%; P=0.7). Conclusions-PCI for SCAD is associated with high rates of technical failure even in those presenting with preserved vessel flow and does not protect against target vessel revascularization or recurrent SCAD. A strategy of conservative management with prolonged observation may be preferable.

Original languageEnglish (US)
Pages (from-to)777-786
Number of pages10
JournalCirculation: Cardiovascular Interventions
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2014

Keywords

  • Acute coronary syndrome
  • Coronary artery dissection spontaneous
  • Percutaneous coronary interventions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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