Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review

Sharonne N. Hayes, Marysia S. Tweet, David Adlam, Esther S.H. Kim, Rajiv Gulati, Joel E. Price, Carl H. Rose

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an important cause of myocardial infarction, particularly among younger women. The pace of knowledge acquisition has been rapid, but ongoing challenges include accurately diagnosing SCAD and improving outcomes. Many SCAD patients experience substantial post-SCAD symptoms, recurrent SCAD, and psychosocial distress. Considerable uncertainty remains about optimal management of associated conditions, risk stratification and prevention of complications, recommendations for physical activity, reproductive planning, and the role of genetic evaluations. This review provides a clinical update on the diagnosis and management of patients with SCAD, including pregnancy-associated SCAD and pregnancy after SCAD, and highlight high-priority knowledge gaps that must be addressed.

Original languageEnglish (US)
Pages (from-to)961-984
Number of pages24
JournalJournal of the American College of Cardiology
Issue number8
StatePublished - Aug 25 2020


  • SCAD
  • fibromuscular dysplasia
  • genetics
  • myocardial infarction
  • pregnancy-associated
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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