TY - JOUR
T1 - Spontaneous Coronary Artery Dissection
T2 - JACC State-of-the-Art Review
AU - Hayes, Sharonne N.
AU - Tweet, Marysia S.
AU - Adlam, David
AU - Kim, Esther S.H.
AU - Gulati, Rajiv
AU - Price, Joel E.
AU - Rose, Carl H.
N1 - Funding Information:
Dr. Kim has served on the Advisory Board for Acer Therapeutics. Dr. Tweet's work is supported by the Building Interdisciplinary Careers in Women's Health (BIRCWH) NIH HD 65987. Dr. Adlam has received in-kind research support from AstraZeneca for SCAD genetics research and from Abbott Vascular to support a clinical research fellow involved in SCAD research; has received research funding from AstraZeneca for unrelated research; and has undertaken consultancy with General Electric Inc. to support general research funds. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Funding Information:
Dr. Kim has served on the Advisory Board for Acer Therapeutics. Dr. Tweet’s work is supported by the Building Interdisciplinary Careers in Women’s Health (BIRCWH) NIH HD 65987. Dr. Adlam has received in-kind research support from AstraZeneca for SCAD genetics research and from Abbott Vascular to support a clinical research fellow involved in SCAD research; has received research funding from AstraZeneca for unrelated research; and has undertaken consultancy with General Electric Inc. to support general research funds. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2020 American College of Cardiology Foundation
PY - 2020/8/25
Y1 - 2020/8/25
N2 - Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an important cause of myocardial infarction, particularly among younger women. The pace of knowledge acquisition has been rapid, but ongoing challenges include accurately diagnosing SCAD and improving outcomes. Many SCAD patients experience substantial post-SCAD symptoms, recurrent SCAD, and psychosocial distress. Considerable uncertainty remains about optimal management of associated conditions, risk stratification and prevention of complications, recommendations for physical activity, reproductive planning, and the role of genetic evaluations. This review provides a clinical update on the diagnosis and management of patients with SCAD, including pregnancy-associated SCAD and pregnancy after SCAD, and highlight high-priority knowledge gaps that must be addressed.
AB - Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an important cause of myocardial infarction, particularly among younger women. The pace of knowledge acquisition has been rapid, but ongoing challenges include accurately diagnosing SCAD and improving outcomes. Many SCAD patients experience substantial post-SCAD symptoms, recurrent SCAD, and psychosocial distress. Considerable uncertainty remains about optimal management of associated conditions, risk stratification and prevention of complications, recommendations for physical activity, reproductive planning, and the role of genetic evaluations. This review provides a clinical update on the diagnosis and management of patients with SCAD, including pregnancy-associated SCAD and pregnancy after SCAD, and highlight high-priority knowledge gaps that must be addressed.
KW - SCAD
KW - fibromuscular dysplasia
KW - genetics
KW - myocardial infarction
KW - pregnancy-associated
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85089214108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089214108&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2020.05.084
DO - 10.1016/j.jacc.2020.05.084
M3 - Review article
C2 - 32819471
AN - SCOPUS:85089214108
SN - 0735-1097
VL - 76
SP - 961
EP - 984
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 8
ER -