Spontaneous coronary artery dissection – From diagnosis to management –

Fernando Alfonso, Teresa Bastante, Fernando Rivero, Javier Cuesta, Amparo Benedicto, Jacqueline Saw, Rajiv Gulati

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Spontaneous coronary artery dissection (SCAD) is a rare but challenging clinical entity of unknown etiology. From a pathophysiological standpoint, SCAD may occur in patients with a coronary intimal tear (presenting with the classic angiographic “flap” and multiple lumens), but also in patients without an intimal rupture (presenting as an intramural hematoma). Until now, available information on SCAD was largely based on multiple, small case-series studies but, recently, data from relatively large registries have cast a new light on this disease. Classically, SCAD was thought to present in young females without traditional atherosclerotic risk factors but recent reports suggest a broader clinical spectrum encompassing older patients with associated coronary artery disease. In this review, we concentrate on 3 main aspects of this unique disease: (1) the value of intracoronary diagnostic techniques (intravascular ultrasound and optical coherence tomography) to complement coronary angiography and to provide novel diagnostic insights on this elusive clinical condition; (2) the growing clinical evidence suggesting an association and potential causation between fibromuscular dysplasia and SCAD; and (3) the challenges of coronary revascularization in this adverse anatomic setting, together with recent data suggesting that a initial, conservative medical management may be preferable for the majority of patients with SCAD.

Original languageEnglish (US)
Pages (from-to)2099-2110
Number of pages12
JournalCirculation Journal
Volume78
Issue number9
DOIs
StatePublished - Sep 1 2014

Fingerprint

Tunica Intima
Fibromuscular Dysplasia
Endovascular Procedures
Optical Coherence Tomography
Coronary Angiography
Causality
Hematoma
Registries
Spontaneous Coronary Artery Dissection
Coronary Artery Disease
Rupture
Light
Conservative Treatment

Keywords

  • Acute coronary syndrome
  • Coronary revascularization
  • Fibromuscular dysplasia
  • Intracoronary diagnostic imaging
  • Spontaneous coronary artery dissection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Alfonso, F., Bastante, T., Rivero, F., Cuesta, J., Benedicto, A., Saw, J., & Gulati, R. (2014). Spontaneous coronary artery dissection – From diagnosis to management –. Circulation Journal, 78(9), 2099-2110. https://doi.org/10.1253/circj.CJ-14-0773

Spontaneous coronary artery dissection – From diagnosis to management –. / Alfonso, Fernando; Bastante, Teresa; Rivero, Fernando; Cuesta, Javier; Benedicto, Amparo; Saw, Jacqueline; Gulati, Rajiv.

In: Circulation Journal, Vol. 78, No. 9, 01.09.2014, p. 2099-2110.

Research output: Contribution to journalReview article

Alfonso, F, Bastante, T, Rivero, F, Cuesta, J, Benedicto, A, Saw, J & Gulati, R 2014, 'Spontaneous coronary artery dissection – From diagnosis to management –', Circulation Journal, vol. 78, no. 9, pp. 2099-2110. https://doi.org/10.1253/circj.CJ-14-0773
Alfonso F, Bastante T, Rivero F, Cuesta J, Benedicto A, Saw J et al. Spontaneous coronary artery dissection – From diagnosis to management –. Circulation Journal. 2014 Sep 1;78(9):2099-2110. https://doi.org/10.1253/circj.CJ-14-0773
Alfonso, Fernando ; Bastante, Teresa ; Rivero, Fernando ; Cuesta, Javier ; Benedicto, Amparo ; Saw, Jacqueline ; Gulati, Rajiv. / Spontaneous coronary artery dissection – From diagnosis to management –. In: Circulation Journal. 2014 ; Vol. 78, No. 9. pp. 2099-2110.
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