Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers

Eitan Friedman, Joanne Kotsopoulos, Jan Lubinski, Henry T. Lynch, Parviz Ghadirian, Susan L. Neuhausen, Claudine Isaacs, Barbara Weber, William D. Foulkes, Pal Moller, Barry Rosen, Charmaine Kim-Sing, Ruth Gershoni-Baruch, Peter Ainsworth, Mary Daly, Nadine Tung, Andrea Eisen, Olufunmilayo I. Olopade, Beth Karlan, Howard M. SaalJudy E. Garber, Gad Rennert, Dawna Gilchrist, Charis Eng, Kenneth Offit, Michael Osborne, Ping Sun, Steven A. Narod, Jane McLennan, David Fishman, Sofia Merajver, Wendy McKinnon, Marie Wood, Albert Chudley, Ellen Warner, Jeffrey Weitzel, Gareth Evans, Edmond Lemire, Hakkan Olsson, Wendy Meschino, Diane Provencher, Gordon Mills, Boris Pasche, Taya Fallen, Barbara Pasini, Cristina Bellati, Fergus Couch, Teresa Wagner, Linda Kipper, Patricia Steele

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Introduction: BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at increased risk of having recurrent (three or more) miscarriages. Several reproductive factors have been shown to influence the risk of breast cancer in mutation carriers, but the effects of spontaneous and therapeutic abortions on the risk of hereditary breast cancer risk have not been well studied to date. Methods: In a matched case-control study, the frequencies of spontaneous abortions were compared among 1,878 BRCA1 mutation carriers, 950 BRCA2 mutation carriers and 657 related non-carrier controls. The rates of spontaneous and therapeutic abortions were compared for carriers with and without breast cancer. Results: There was no difference in the rate of spontaneous abortions between carriers of BRCA1 or BRCA2 mutations and non-carriers. The number of spontaneous abortions was not associated with breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, BRCA2 carriers who had two or more therapeutic abortions faced a 64% decrease in the risk of breast cancer (odds ratio = 0.36; 95% confidence interval 0.16-0.83; p = 0.02). Conclusion: Carrying a BRCA1 or BRCA2 mutation is not a risk factor for spontaneous abortions and spontaneous abortions do not appear to influence the risk of breast cancer in carriers of BRCA1 or BRCA2 mutations. However, having two or more therapeutic abortions may be associated with a lowered risk of breast cancer among BRCA2 carriers.

Original languageEnglish (US)
Article numberR15
JournalBreast Cancer Research
Volume8
Issue number2
DOIs
StatePublished - Mar 21 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Friedman, E., Kotsopoulos, J., Lubinski, J., Lynch, H. T., Ghadirian, P., Neuhausen, S. L., Isaacs, C., Weber, B., Foulkes, W. D., Moller, P., Rosen, B., Kim-Sing, C., Gershoni-Baruch, R., Ainsworth, P., Daly, M., Tung, N., Eisen, A., Olopade, O. I., Karlan, B., ... Steele, P. (2006). Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Research, 8(2), [R15]. https://doi.org/10.1186/bcr1387