Splenic small B-cell lymphoma with IGH/BCL3 translocation

Lorinda A. Soma, Susanne M. Gollin, Ellen D. Remstein, Rhett P. Ketterling, Heather C. Flynn, Kiran K. Rajasenan, Steven H. Swerdlow

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Isolated chromosomal translocations are important defining features of many non-Hodgkin lymphomas, especially of B-cell type. In contrast to some other translocations, the significance of IGH/BCL3 translocations is not well defined. Although often considered a feature of the ill-defined entity atypical chronic lymphocytic leukemia, very few cases are reported in which involvement of BCL3 and the precise B-cell neoplasm are both well documented. For this reason, we report a splenic-based CD5-, CD10-, CD43-, CD23-, CD103-, FMC7+, CD25+ small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies. The previously reported neoplasms with t(14;19)(q32;q13) or IGH/BCL3 translocations are also reviewed. The present case did not fall into any of the classic B-cell lymphoma categories and clearly did not represent chronic lymphocytic leukemia/small lymphocytic lymphoma. This case suggests that the IGH/BCL3 translocation may help to define a new clinicopathologic entity.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalHuman Pathology
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2006

Keywords

  • B cells
  • BCL3
  • Cytogenetics
  • Fluorescence in situ hybridization
  • Splenic lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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