Splenic small B-cell lymphoma with IGH/BCL3 translocation

Lorinda A. Soma, Susanne M. Gollin, Ellen McPhail, Rhett P. Ketterling, Heather C. Flynn, Kiran K. Rajasenan, Steven H. Swerdlow

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Isolated chromosomal translocations are important defining features of many non-Hodgkin lymphomas, especially of B-cell type. In contrast to some other translocations, the significance of IGH/BCL3 translocations is not well defined. Although often considered a feature of the ill-defined entity atypical chronic lymphocytic leukemia, very few cases are reported in which involvement of BCL3 and the precise B-cell neoplasm are both well documented. For this reason, we report a splenic-based CD5-, CD10-, CD43-, CD23-, CD103-, FMC7+, CD25+ small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies. The previously reported neoplasms with t(14;19)(q32;q13) or IGH/BCL3 translocations are also reviewed. The present case did not fall into any of the classic B-cell lymphoma categories and clearly did not represent chronic lymphocytic leukemia/small lymphocytic lymphoma. This case suggests that the IGH/BCL3 translocation may help to define a new clinicopathologic entity.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalHuman Pathology
Volume37
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

B-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Genetic Translocation
Paintings
Histiocytes
Fluorescence In Situ Hybridization
Cytogenetics
Non-Hodgkin's Lymphoma
Neoplasms

Keywords

  • B cells
  • BCL3
  • Cytogenetics
  • Fluorescence in situ hybridization
  • Splenic lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Soma, L. A., Gollin, S. M., McPhail, E., Ketterling, R. P., Flynn, H. C., Rajasenan, K. K., & Swerdlow, S. H. (2006). Splenic small B-cell lymphoma with IGH/BCL3 translocation. Human Pathology, 37(2), 218-230. https://doi.org/10.1016/j.humpath.2005.09.025

Splenic small B-cell lymphoma with IGH/BCL3 translocation. / Soma, Lorinda A.; Gollin, Susanne M.; McPhail, Ellen; Ketterling, Rhett P.; Flynn, Heather C.; Rajasenan, Kiran K.; Swerdlow, Steven H.

In: Human Pathology, Vol. 37, No. 2, 02.2006, p. 218-230.

Research output: Contribution to journalArticle

Soma, LA, Gollin, SM, McPhail, E, Ketterling, RP, Flynn, HC, Rajasenan, KK & Swerdlow, SH 2006, 'Splenic small B-cell lymphoma with IGH/BCL3 translocation', Human Pathology, vol. 37, no. 2, pp. 218-230. https://doi.org/10.1016/j.humpath.2005.09.025
Soma LA, Gollin SM, McPhail E, Ketterling RP, Flynn HC, Rajasenan KK et al. Splenic small B-cell lymphoma with IGH/BCL3 translocation. Human Pathology. 2006 Feb;37(2):218-230. https://doi.org/10.1016/j.humpath.2005.09.025
Soma, Lorinda A. ; Gollin, Susanne M. ; McPhail, Ellen ; Ketterling, Rhett P. ; Flynn, Heather C. ; Rajasenan, Kiran K. ; Swerdlow, Steven H. / Splenic small B-cell lymphoma with IGH/BCL3 translocation. In: Human Pathology. 2006 ; Vol. 37, No. 2. pp. 218-230.
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