@article{6ccff093c29b46d995a388b3e2aa64ca,
title = "Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation",
abstract = "Background and purpose: Spiral MR imaging has several advantages compared with Cartesian MR imaging that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral with standard-of-care Cartesian postcontrast structural brain MR imaging on the basis of relative performance in 10 metrics of image quality, artifact prevalence, and diagnostic benefit. Materials and methods: Seven clinical sites acquired 88 total subjects. For each subject, sites acquired 2 postcontrast MR imaging scans: a spiral 2D T1 spin-echo, and 1 of 4 routine Cartesian 2D T1 spin-echo/TSE scans (fully sampled spin-echo at 3T, 1.5T, partial Fourier, TSE). The spiral acquisition matched the Cartesian scan for scan time, geometry, and contrast. Nine neuroradiologists independently reviewed each subject, with the matching pair of spiral and Cartesian scans compared side-by-side, and scored on 10 image-quality metrics (5-point Likert scale) focused on intracranial assessment. The Wilcoxon signed rank test evaluated relative performance of spiral versus Cartesian, while the Kruskal-Wallis test assessed interprotocol differences. Results: Spiral was superior to Cartesian in 7 of 10 metrics (flow artifact mitigation, SNR, GM/WM contrast, image sharpness, lesion conspicuity, preference for diagnosing abnormal enhancement, and overall intracranial image quality), comparable in 1 of 10 metrics (motion artifacts), and inferior in 2 of 10 metrics (susceptibility artifacts, overall extracranial image quality) related to magnetic susceptibility (P < .05). Interprotocol comparison confirmed relatively higher SNR and GM/WM contrast for partial Fourier and TSE protocol groups, respectively (P < .05). Conclusions: Spiral 2D T1 spin-echo for routine structural brain MR imaging is feasible in the clinic with conventional scanners and was preferred by neuroradiologists for overall postcontrast intracranial evaluation.",
author = "Ooi, {M. B.} and Z. Li and Robison, {R. K.} and D. Wang and Anderson, {A. G.} and Zwart, {N. R.} and A. Bakhru and S. Nagaraj and T. Mathews and S. Hey and Koonen, {J. J.} and Dimitrov, {I. E.} and Friel, {H. T.} and Q. Lu and M. Obara and I. Saha and H. Wang and Y. Wang and Y. Zhao and M. Temkit and Hu, {H. H.} and Chenevert, {T. L.} and O. Togao and Tkach, {J. A.} and Nagaraj, {U. D.} and Pinho, {M. C.} and Gupta, {R. K.} and Small, {J. E.} and Kunst, {M. M.} and Karis, {J. P.} and Andre, {J. B.} and Miller, {J. H.} and Pinter, {N. K.} and Pipe, {J. G.}",
note = "Funding Information: Disclosures: Melvyn B. Ooi—RELATED: Grant: Philips Healthcare, Comments: This work was funded, in part, by Philips Healthcare, paid to Barrow Neurological Institute and Mayo Clinic*; UNRELATED: Employment: Philips Healthcare. Zhiqiang Li—RELATED: Grant: Philips Healthcare, Comments: grant and research support.* Ryan K. Robison—RELATED: Grant: Philips Healthcare, Comments: Grant funding from Philips Healthcare related to this work occurred at my previous institution and was prior to the data acquisition, analysis, and manuscript revision specific to this submission.* Dinghui Wang—RELATED: Grant: Philips Healthcare, Comments: Research support from Philips Healthcare.* Ashley G. Anderson—RELATED: Grant: Philips Healthcare, Comments: This work was supported by a grant from Philips Healthcare*; Support for Travel to Meetings for the Study or Other Purposes: Philips Healthcare, Comments: I participated in several conferences, and my travel was funded by grants from Philips Healthcare*; UNRELATED: Employment: Philips Healthcare, Hyperfine Research, Inc. Stock/Stock Options: Philips Healthcare, Hyperfine Research, Inc, Comments: I was employed by Philips Healthcare for some of the time during preparation of this article. At the time of submission, I am an employee of another medical imaging company, Hyperfine Research, Inc. As part of my regular compensation, I have received stock options and participated in employee stock purchase programs. Silke Hey—UNRELATED: Employment: Philips Healthcare Netherlands. Jos Koonen—RELATED: Grant: Eureka, Comments: Eureka Cluster Program ITEA, project STARLIT (16016).* Nandor K. Pinter—UNRELATED: Payment for Lectures Including Service on Speakers Bureaus: Philips Healthcare. James G. Pipe— RELATED: Grant: Philips Healthcare.* Ivan Dimitrov—UNRELATED: Employment: Philips Healthcare. Quin Lu—UNRELATED: Employment: Philips Healthcare; Stock/ Stock Options: Philips Healthcare. Yansong Zhao—UNRELATED: Employment: Philips Healthcare. Hui Wang—UNRELATED: Employment: Philips Healthcare. Nicholas R. Zwart—RELATED: Grant: Philips Healthcare*; Support for Travel to Meetings for the Study or Other Purposes: Philips Healthcare.* Yi Wang—UNRELATED: Employment: Philips Healthcare. Jalal B. Andre—UNRELATED: Grants/Grants Pending: Philips Healthcare, Comments: research grant.* Thomas L. Chenevert—UNRELATED: Patents (Planned, Pending or Issued): Patent unrelated to this work was licensed to Philips Healthcare, Comments: no money paid. Makoto Obara—OTHER RELATIONSHIPS: I am a Philips Japan employee. *Money paid to institution. Funding Information: The spiral pulse sequence and reconstruction algorithm is a collaborative “work-in-progress,” developed by the Barrow Neurological Institute and Mayo Clinic (Z.L., D.W., N.R.Z., R.K.R., A.G.A., M.B.O., J.G.P.) and funded, in part, by Philips Healthcare. Publisher Copyright: {\textcopyright} 2020 American Society of Neuroradiology. All rights reserved.",
year = "2020",
month = feb,
day = "1",
doi = "10.3174/ajnr.A6409",
language = "English (US)",
volume = "41",
pages = "238--245",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "2",
}