Spinal meningiomas in patients younger than 50 years of age: A 21-year experience

Aaron A. Cohen-Gadol, Ofer M. Zikel, Cody A. Koch, Bernd W. Scheithauer, William E. Krauss

Research output: Contribution to journalArticle

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Abstract

Object. Spinal meningiomas occur most frequently in older patients. They are well-circumscribed and slow-growing tumors that are associated with good patient outcomes following surgery. Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age. Methods. The authors reviewed data obtained in 40 patients (age < 50 years) treated at the Mayo Clinic, Rochester, during the past 21 years; in all cases the lesions were histologically confirmed spinal meningiomas. Five men (12.5%) and 35 women (87.5%) (mean age 34.5 ± 10.9 years) underwent 52 operations for 41 tumors. The mean follow-up duration was 82 ± 93 months (range 0-445 months). The data obtained in these patients were compared with those derived from a random control cohort of 40 patients older than age 50 years in whom spinal meningiomas were resected at the Mayo Clinic during a similar period. In this cohort, there were 33 women and seven men whose mean age was 67.1 ± 9.5 years. The mean follow-up duration for the older group was 88 ± 72.3 months (range 18-309 months). Compared with the random cohort of older patients, younger patients there tended to have more tumors located in the cervical spine (39%) as well as a greater number of predisposing factors such as neurofibromatosis Type 2, radiation exposure, or trauma. Nine (22%) of the patients younger than 50 years of age required reoperation for residual or recurrent tumor compared with two (5%) in the older patient control group. The overall mortality rate at the completion of the study for the younger patients was 10%. Conclusions. Spinal meningiomas in younger patients have a worse prognosis than similar tumors in older patients.

Original languageEnglish (US)
Pages (from-to)258-263
Number of pages6
JournalJournal of Neurosurgery
Volume98
Issue number3 SUPPL.
StatePublished - Apr 1 2003

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Meningioma
Neoplasms
Neurofibromatosis 2
Reoperation
Causality
Spine

Keywords

  • Ionizing radiation
  • Meningioma
  • Neurofibromatosis Type 2
  • Spine
  • Trauma

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Clinical Neurology

Cite this

Cohen-Gadol, A. A., Zikel, O. M., Koch, C. A., Scheithauer, B. W., & Krauss, W. E. (2003). Spinal meningiomas in patients younger than 50 years of age: A 21-year experience. Journal of Neurosurgery, 98(3 SUPPL.), 258-263.

Spinal meningiomas in patients younger than 50 years of age : A 21-year experience. / Cohen-Gadol, Aaron A.; Zikel, Ofer M.; Koch, Cody A.; Scheithauer, Bernd W.; Krauss, William E.

In: Journal of Neurosurgery, Vol. 98, No. 3 SUPPL., 01.04.2003, p. 258-263.

Research output: Contribution to journalArticle

Cohen-Gadol, AA, Zikel, OM, Koch, CA, Scheithauer, BW & Krauss, WE 2003, 'Spinal meningiomas in patients younger than 50 years of age: A 21-year experience', Journal of Neurosurgery, vol. 98, no. 3 SUPPL., pp. 258-263.
Cohen-Gadol AA, Zikel OM, Koch CA, Scheithauer BW, Krauss WE. Spinal meningiomas in patients younger than 50 years of age: A 21-year experience. Journal of Neurosurgery. 2003 Apr 1;98(3 SUPPL.):258-263.
Cohen-Gadol, Aaron A. ; Zikel, Ofer M. ; Koch, Cody A. ; Scheithauer, Bernd W. ; Krauss, William E. / Spinal meningiomas in patients younger than 50 years of age : A 21-year experience. In: Journal of Neurosurgery. 2003 ; Vol. 98, No. 3 SUPPL. pp. 258-263.
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abstract = "Object. Spinal meningiomas occur most frequently in older patients. They are well-circumscribed and slow-growing tumors that are associated with good patient outcomes following surgery. Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age. Methods. The authors reviewed data obtained in 40 patients (age < 50 years) treated at the Mayo Clinic, Rochester, during the past 21 years; in all cases the lesions were histologically confirmed spinal meningiomas. Five men (12.5{\%}) and 35 women (87.5{\%}) (mean age 34.5 ± 10.9 years) underwent 52 operations for 41 tumors. The mean follow-up duration was 82 ± 93 months (range 0-445 months). The data obtained in these patients were compared with those derived from a random control cohort of 40 patients older than age 50 years in whom spinal meningiomas were resected at the Mayo Clinic during a similar period. In this cohort, there were 33 women and seven men whose mean age was 67.1 ± 9.5 years. The mean follow-up duration for the older group was 88 ± 72.3 months (range 18-309 months). Compared with the random cohort of older patients, younger patients there tended to have more tumors located in the cervical spine (39{\%}) as well as a greater number of predisposing factors such as neurofibromatosis Type 2, radiation exposure, or trauma. Nine (22{\%}) of the patients younger than 50 years of age required reoperation for residual or recurrent tumor compared with two (5{\%}) in the older patient control group. The overall mortality rate at the completion of the study for the younger patients was 10{\%}. Conclusions. Spinal meningiomas in younger patients have a worse prognosis than similar tumors in older patients.",
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T1 - Spinal meningiomas in patients younger than 50 years of age

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AU - Cohen-Gadol, Aaron A.

AU - Zikel, Ofer M.

AU - Koch, Cody A.

AU - Scheithauer, Bernd W.

AU - Krauss, William E.

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N2 - Object. Spinal meningiomas occur most frequently in older patients. They are well-circumscribed and slow-growing tumors that are associated with good patient outcomes following surgery. Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age. Methods. The authors reviewed data obtained in 40 patients (age < 50 years) treated at the Mayo Clinic, Rochester, during the past 21 years; in all cases the lesions were histologically confirmed spinal meningiomas. Five men (12.5%) and 35 women (87.5%) (mean age 34.5 ± 10.9 years) underwent 52 operations for 41 tumors. The mean follow-up duration was 82 ± 93 months (range 0-445 months). The data obtained in these patients were compared with those derived from a random control cohort of 40 patients older than age 50 years in whom spinal meningiomas were resected at the Mayo Clinic during a similar period. In this cohort, there were 33 women and seven men whose mean age was 67.1 ± 9.5 years. The mean follow-up duration for the older group was 88 ± 72.3 months (range 18-309 months). Compared with the random cohort of older patients, younger patients there tended to have more tumors located in the cervical spine (39%) as well as a greater number of predisposing factors such as neurofibromatosis Type 2, radiation exposure, or trauma. Nine (22%) of the patients younger than 50 years of age required reoperation for residual or recurrent tumor compared with two (5%) in the older patient control group. The overall mortality rate at the completion of the study for the younger patients was 10%. Conclusions. Spinal meningiomas in younger patients have a worse prognosis than similar tumors in older patients.

AB - Object. Spinal meningiomas occur most frequently in older patients. They are well-circumscribed and slow-growing tumors that are associated with good patient outcomes following surgery. Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age. Methods. The authors reviewed data obtained in 40 patients (age < 50 years) treated at the Mayo Clinic, Rochester, during the past 21 years; in all cases the lesions were histologically confirmed spinal meningiomas. Five men (12.5%) and 35 women (87.5%) (mean age 34.5 ± 10.9 years) underwent 52 operations for 41 tumors. The mean follow-up duration was 82 ± 93 months (range 0-445 months). The data obtained in these patients were compared with those derived from a random control cohort of 40 patients older than age 50 years in whom spinal meningiomas were resected at the Mayo Clinic during a similar period. In this cohort, there were 33 women and seven men whose mean age was 67.1 ± 9.5 years. The mean follow-up duration for the older group was 88 ± 72.3 months (range 18-309 months). Compared with the random cohort of older patients, younger patients there tended to have more tumors located in the cervical spine (39%) as well as a greater number of predisposing factors such as neurofibromatosis Type 2, radiation exposure, or trauma. Nine (22%) of the patients younger than 50 years of age required reoperation for residual or recurrent tumor compared with two (5%) in the older patient control group. The overall mortality rate at the completion of the study for the younger patients was 10%. Conclusions. Spinal meningiomas in younger patients have a worse prognosis than similar tumors in older patients.

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KW - Meningioma

KW - Neurofibromatosis Type 2

KW - Spine

KW - Trauma

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