Spinal cord injury in vitro: Modelling axon growth inhibition

Mohammad Abu-Rub, Siobhan McMahon, Dimitrios I. Zeugolis, Anthony Windebank, Abhay Pandit

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.

Original languageEnglish (US)
Pages (from-to)436-443
Number of pages8
JournalDrug Discovery Today
Volume15
Issue number11-12
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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