TY - JOUR
T1 - Spinal cord injury in vitro
T2 - Modelling axon growth inhibition
AU - Abu-Rub, Mohammad
AU - McMahon, Siobhan
AU - Zeugolis, Dimitrios I.
AU - Windebank, Anthony
AU - Pandit, Abhay
PY - 2010/6
Y1 - 2010/6
N2 - Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.
AB - Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. Various in vitro assays have been developed using brain and/or spinal cord neuronal cells to study axon growth in conditions that represent the post-injury environment. This review outlines the current models used to dissect, analyze and manipulate specific aspects of spinal cord injury leading to axon growth inhibition.
UR - http://www.scopus.com/inward/record.url?scp=77954814754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954814754&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2010.03.008
DO - 10.1016/j.drudis.2010.03.008
M3 - Review article
C2 - 20346411
AN - SCOPUS:77954814754
SN - 1359-6446
VL - 15
SP - 436
EP - 443
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 11-12
ER -