Abstract
Background: Coupling of bone degradation to subsequent bone formation requires recruitment of osteoblast precursors. Results: Osteoclasts produce sphingosine 1-phosphate (S1P), which stimulates mesenchymal (skeletal) stem cell migration by activating kinase signaling pathways. Conclusion: Coupling of bone resorption to bone formation involves S1P-mediated recruitment of osteoblastic cells. Significance: Enhancing kinase signaling in osteoblastic cells may be a novel approach to enhance bone formation.
Original language | English (US) |
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Pages (from-to) | 5398-5406 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 8 |
DOIs | |
State | Published - Feb 22 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology