Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Ptrick Quint, Ming Ruan, Larry Pederson, Moustapha Kassem, Jennifer J. Westendorf, Sundeep Khosla, Merry Jo Oursler

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Background: Coupling of bone degradation to subsequent bone formation requires recruitment of osteoblast precursors. Results: Osteoclasts produce sphingosine 1-phosphate (S1P), which stimulates mesenchymal (skeletal) stem cell migration by activating kinase signaling pathways. Conclusion: Coupling of bone resorption to bone formation involves S1P-mediated recruitment of osteoblastic cells. Significance: Enhancing kinase signaling in osteoblastic cells may be a novel approach to enhance bone formation.

Original languageEnglish (US)
Pages (from-to)5398-5406
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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